Results 21 to 30 of about 9,645,786 (257)

Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor, which signals through elevating intracellular cAMP levels, and expressed in most vertebrates, including rodents and humans.
Stefano Espinoza, Damiana Leo, Damiana Leo, Tatyana D. Sotnikova, Mohammed Shahid, Tiina M. Kääriäinen, Raul R. Gainetdinov, Raul R. Gainetdinov   +7 more
doaj   +3 more sources

Natural variability of trace-amine associated receptors in wild meerkats

Frontiers in Zoology
Background The study of olfaction as a sensory modality has been relatively neglected in comparison to other sensory cues, particularly in wildlife research.
Johannes Fähnle, Kerstin Wilhelm, Benedikt Wiese, Marta Manser, Tim Clutton-Brock, Simone Sommer, Nadine Müller-Klein   +6 more
doaj   +4 more sources

TRACE AMINE-ASSOCIATED RECEPTOR 9 ROLE IN THERMOREGULATION

IBRO Neuroscience Reports, 2023
Ramilya Murtazina, Evgeniya Efimova, Mikael Mor, Raul Gainetdinov   +3 more
doaj   +2 more sources

Deorphanization of Olfactory Trace Amine-Associated Receptors [PDF]

The Journal of Neuroscience, 2018
Olfaction is the primary sense used by most animals to perceive the external world. The mouse olfactory system is composed of several sensory structures, the largest of which is the main olfactory epithelium (MOE). Olfactory sensory neurons (OSNs) located within the MOE detect odors and pheromones using dedicated seven-transmembrane G protein-coupled ...
Jingji, Zhang, Rodrigo, Pacifico, Dillon, Cawley, Paul, Feinstein, Thomas, Bozza   +4 more
  +6 more sources

Trace amine receptor in GtoPdb v.2023.1 [PDF]

, 2023
Trace amine-associated receptors were discovered from a search for novel 5-HT receptors [9], where 15 mammalian orthologues were identified and divided into two families.
Anthony P. Davenport, Maguire, Janet J., Parker, William A.E., Tom I. Bonner, Davenport, Anthony P., Bonner, Tom I., Foord, Stephen M., Stephen M. Foord, Janet J. Maguire, William A.E. Parker   +9 more
core   +1 more source

Collective and Coordinated Conformational Changes Determine Agonism or Antagonism at the Human Trace Amine-Associated Receptor 1. [PDF]

ACS Omega, 2023
The human trace amine-associated receptor (hTAAR1), a G protein-coupled receptor, has been postulated as a new target in the treatment of neuropsychiatric conditions.
Robles AI, Dinamarca-Villarroel L, Torres GE, Fierro A.   +3 more
europepmc   +3 more sources

Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases [PDF]

, 2018
The trace amines, endogenous amines closely related to the biogenic amine neurotransmitters, have been known to exert physiological and neurological effects for decades.
Espinoza, S (15579317), Schwartz, MD (15748640), Sukhanov, I (15748646), Gainetdinov, RR (15665189), Canales, JJ (15665159), Zucchi, R (15748643)   +5 more
core   +3 more sources

Elucidating the molecular pharmacology of trace amine‐associated receptor 1 to advance antipsychotic drug discovery [PDF]

Clinical and Translational Medicine
Jingjing Yu, Zheng Xu, Wei Yan, Zhenhua Shao   +3 more
doaj   +2 more sources

AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1. [PDF]

Sci Adv
Artificial intelligence is revolutionizing protein structure prediction, providing unprecedented opportunities for drug design. To assess the potential impact on ligand discovery, we compared virtual screens using protein structures generated by the ...
Díaz-Holguín A, Saarinen M, Vo DD, Sturchio A, Branzell N, Cabeza de Vaca I, Hu H, Mitjavila-Domènech N, Lindqvist A, Baranczewski P, Millan MJ, Yang Y, Carlsson J, Svenningsson P.   +13 more
europepmc   +2 more sources

Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain

Biomolecules, 2022
G protein-coupled trace amine-associated receptors (TAAR) recognize different classes of amine compounds, including trace amines or other exogenous and endogenous molecules.
Anastasia N. Vaganova, Nataliia V. Katolikova, Ramilya Z. Murtazina, Savelii R. Kuvarzin, Raul R. Gainetdinov   +4 more
doaj   +1 more source