Results 41 to 50 of about 9,645,786 (257)

The trace amine-associated receptor 1 modulates methamphetamine’s neurochemical and behavioural effects

Frontiers in Neuroscience, 2015
The newly discovered trace amine-associated receptor 1 (TAAR1) has the ability to regulate both dopamine function and psychostimulant action. Here, we tested in rats the ability of RO5203648, a selective TAAR1 partial agonist, to modulate the ...
Rachel eCotter, Yue ePei, Yue ePei, Liudmila eMus, Anja eHarmeier, Raul eGainetdinov, Marius Christian Hoener, Juan J Canales   +7 more
doaj   +1 more source

Study of two G-protein coupled receptor variants of human trace amine-associated receptor 5 [PDF]

, 2011
Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines.
Karolina Corin, Shuguang Zhang, Wang, Xiaoqiang, Cyrus Rich, Zhang, Shuguang, Corin, Karolina A., Rich, Cyrus, Xiaoqiang Wang   +7 more
core   +1 more source

Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine

Frontiers in Pharmacology, 2018
Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity.
Michael D. Schwartz, Jeremiah B. Palmerston, Diana L. Lee, Marius C. Hoener, Thomas S. Kilduff   +4 more
doaj   +1 more source

Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.

PLoS ONE, 2016
Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and β-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1).
Xiao Shi, Nicole A R Walter, John H Harkness, Kim A Neve, Robert W Williams, Lu Lu, John K Belknap, Amy J Eshleman, Tamara J Phillips, Aaron Janowsky   +9 more
doaj   +1 more source

Trace amine receptor in GtoPdb v.2025.3 [PDF]

Trace amine-associated receptors were discovered from a search for novel 5-HT receptors [9], where 15 mammalian orthologues were identified and divided into two families.
Maguire, Janet J., Parker, William A.E., Davenport, Anthony P., Bonner, Tom I., Foord, Stephen M.   +4 more
core   +1 more source

Trace amine associated receptor 1 (TAAR1), a novel astrocyte receptor for METH-mediated neurotoxicity in HIV-1-associated neurocognitive disorders (HAND) [PDF]

, 2015
This dissertation explores the role of astrocyte trace amine associated receptor 1 (TAAR1), a novel G-protein coupled receptor (GPCR), in modulating the effects of methamphetamine (METH) on astrocyte-mediated excitotoxicity, thereby exacerbating HIV ...
Cisneros, Irma E.
core   +2 more sources

Olfactory signaling via trace amine-associated receptors

Cell and Tissue Research, 2020
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors that function as odorant receptors in the main olfactory system of vertebrates. TAARs are monoallelically expressed in primary sensory neurons where they couple to the same transduction cascade as canonical olfactory receptors and are mapped onto glomeruli within a ...
openaire   +3 more sources

Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes [PDF]

Journal of Neuroimmune Pharmacology, 2011
Although most research to date on Trace Amine Associated Receptor 1 (TAAR1) has focused on its role in the brain, it has been recognized since its discovery in 2001 that TAAR1 mRNA is expressed in peripheral tissues as well, suggesting that this receptor may play a role in non-neurological pathways.
Michael W, Panas, Zhihua, Xie, Helen N, Panas, Marius C, Hoener, Eric J, Vallender, Gregory M, Miller   +5 more
openaire   +2 more sources

Imaging the trace amine-associated receptor 1 by positron emission tomography

, 2021
Trace amine-associated receptor 1 (TAAR1) has been implicated in drug addiction, schizophrenia, depression and Parkinson’s disease (PD). To date, there are no reports on TAAR1-targeted probes for non-invasive quantification of receptor density in vivo ...
Xu, Hao, Chen, Jiahui, Xiao, Zhiwei, 1027060, Lu, Wang, 1027061, Zhang, Ming-Rong, 1027066, 1027067, Rong, Jiang, 1027068, 1027062, 1027063, 1027064, 1027065, 1027059, Haider, Ahmed, 1027055, 1027056, Sun, Jiyun, Katsushi, Kumata, 1027057, 1027058, Shao, Tuo, Liang, Huan, 1027054   +25 more
core   +1 more source

TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats

Frontiers in Pharmacology
IntroductionDespite their association with brain disorders, the neurophysiological roles of the trace amine-associated receptors remain poorly understood.
Ilya S. Zhukov, Ilya S. Zhukov, Inessa V. Karpova, Ramilya Z. Murtazina, Yazen Alnefeesi, Olga M. Korenkova, Ilia Yu. Tissen, Svetlana A. Palchikova, Lydia A. Tokareva, Sarng S. Pyurveev, Petr D. Shabanov, Larisa G. Kubarskaya, Larisa G. Kubarskaya, Mikhail A. Rozhko, Ekaterina B. Zernova, Ekaterina A. Zolotoverkhaja, Anna B. Volnova, Allan V. Kalueff, Natalia V. Alenina, Raul R. Gainetdinov, Raul R. Gainetdinov   +20 more
doaj   +1 more source