Results 51 to 60 of about 9,645,786 (257)

Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics [PDF]

Biological Psychiatry, 2017
Narcolepsy, a disorder of rapid eye movement (REM) sleep, is characterized by excessive daytime sleepiness and cataplexy, a loss of muscle tone triggered by emotional stimulation. Current narcolepsy pharmacotherapeutics include controlled substances with abuse potential or drugs with undesirable side effects.
Sarah W, Black, Michael D, Schwartz, Tsui-Ming, Chen, Marius C, Hoener, Thomas S, Kilduff   +4 more
openaire   +2 more sources

Modified Chromenes as Precursors to TAAR Regulators [PDF]

, 2011
200 million people worldwide are living with a thyroid disorder related to a hormonal imbalance. Symptoms of this imbalance include deviations from normal heart rates and metabolic rates.
Lehmann, Jonathan, Hart, Matthew
core  

Trace amine-associated receptor 1 (TAAR1): a new drug target for psychiatry?

, 2021
Trace amine-associated receptor 1 (TAAR1): a new drug target for ...
Seetal Dodd (13093767), AF Carvalho (13973112), Chiara Bortolasci (13060449), G Morris (12709208), BK Puri (14445966), M Maes (13320648), Michael Berk (13060851)   +6 more
core  

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (Taar1) has been suggested as putative receptor of thyronamines. These are aminergic messengers with potential metabolic and neurological effects countering their contingent precursors, the thyroid hormones (THs ...
Maria Qatato, Joanna Szumska, Vladislav Skripnik, Eddy Rijntjes, Josef Köhrle, Klaudia Brix   +5 more
doaj   +1 more source

Biological evaluation and in silico studies of novel compounds as potent TAAR1 agonists that could be used in schizophrenia treatment

Frontiers in Pharmacology, 2023
Introduction: Schizophrenia is a serious mental illness that requires effective treatment with minimal adverse effects. As preclinical and clinical research progresses, trace amine-associated receptor 1 (TAAR1) is becoming a potential new target for the ...
Yunjie Wang, Zhaofeng Liu, Jing Lu, Wenyan Wang, Lin Wang, Yifei Yang, Hongbo Wang, Liang Ye, Jianzhao Zhang, Jingwei Tian   +9 more
doaj   +1 more source

From Food to Power: Hydrogel Thermoelectrics for Ingestible Electronics

Advanced Functional Materials, EarlyView.
We introduce a fully edible thermoelectric–electrochromic platform that harvests heat from food and converts it into a visible color change. N‐type and p‐type hydrogel thermoelectric generators connected in series power anthocyanin‐based electrochromic displays, demonstrating the feasibility of safe, biodegradable, ingestible systems for on‐food ...
Antonia Georgopoulou, Bokeon Kwak, Dario Floreano, Esther Amstad   +3 more
wiley   +1 more source

Trace amine-associated receptor 1 (TAAR1) agonists

Archives of Psychiatry Research, 2022
Overview of current developments about trace amine- associated receptor 1 (TAAR1 ...
Peitl, Vjekoslav, Vlahović, Darko
openaire   +3 more sources

Optoelectronic Synaptic Devices Using Molecular Telluride Phase‐Change Inks for Three‐Factor Learning

Advanced Functional Materials, EarlyView.
Optoelectronic synaptic devices based on solution‐processed molecular telluride GST‐225 phase‐change inks are demonstrated for three‐factor learning. A global optical signal broadcast through a silicon waveguide induces non‐volatile conductance updates exclusively in locally electrically flagged memristors.
Kevin Portner, Dhananjeya Kumaar, Giacomo Torti, Killian Keller, Till Zellweger, Florian M. Schenk, Christoph Weilenmann, Daniel Chelladurai, Vara Prasad Jonnalagadda, Ghazi Sarwat Syed, Vanessa Wood, Jürg Leuthold, Alexandros Emboras, Maksym Yarema, Mathieu Luisier   +14 more
wiley   +1 more source

Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising target for addiction treatments because it affects dopamine transmission in the mesolimbic pathway.
Ilya Sukhanov, Ilya Sukhanov, Ilya Sukhanov, Mariia Dorofeikova, Antonina Dolgorukova, Artem Dorotenko, Raul R. Gainetdinov, Raul R. Gainetdinov   +7 more
doaj   +1 more source