Results 11 to 20 of about 9,645,786 (257)

Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f [PDF]

Nature Communications
There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs).
Anastasiia Gusach, Yang Lee, Armin Nikpour Khoshgrudi, Elizaveta Mukhaleva, Ning Ma, Eline J. Koers, Qingchao Chen, Patricia C. Edwards, Fanglu Huang, Jonathan Kim, Filippo Mancia, Dmitry B. Veprintsev, Nagarajan Vaidehi, Simone N. Weyand, Christopher G. Tate   +14 more
doaj   +11 more sources

Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol [PDF]

Substance Abuse: Research and Treatment, 2013
Background Few treatment options for alcohol use disorders (AUDs) exist and more are critically needed. Here, we assessed whether trace amine associated receptor 1 (TAAR1), a modulator of brain monoamine systems, is involved in the behavioral and ...
Laurie J. Lynch, Katherine A. Sullivan, Eric J. Vallender, James K. Rowlett, Donna M. Platt, Gregory M. Miller   +5 more
doaj   +3 more sources

Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs [PDF]

BMC Evolutionary Biology, 2010
Background The trace amine associated receptor family is a diverse array of GPCRs that arose before the first vertebrates walked on land. Trace amine associated receptor 1 (TAAR1) is a wide spectrum aminergic receptor that acts as a modulator in brain ...
Westmoreland Susan V, Xie Zhihua, Vallender Eric J, Miller Gregory M   +3 more
doaj   +2 more sources

Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice [PDF]

Scientific Reports, 2022
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain ...
Silvia Maggi, Carlotta Bon, Stefano Gustincich, Valter Tucci, Raul R. Gainetdinov, Stefano Espinoza   +5 more
doaj   +2 more sources

Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward

Frontiers in Pharmacology, 2018
Eating disorders and some forms of obesity are characterized by addictive-like, compulsive eating behavior which contains numerous similarities with compulsive drug use.
Catherine F. Moore, Catherine F. Moore, Valentina Sabino, Pietro Cottone   +3 more
doaj   +2 more sources

Unlocking the secrets of trace amine-associated receptor 1 agonists: new horizon in neuropsychiatric treatment [PDF]

Frontiers in Psychiatry
For over seven decades, dopamine receptor 2 (D2 receptor) antagonists remained the mainstay treatment for neuropsychiatric disorders. Although it is effective for treating hyperdopaminergic symptoms, it is often ineffective for treating negative and ...
Britto Shajan, Tarun Bastiampillai, Tarun Bastiampillai, Shane D. Hellyer, Pramod C. Nair, Pramod C. Nair, Pramod C. Nair, Pramod C. Nair   +7 more
doaj   +2 more sources

Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.

PLoS ONE, 2011
Trace amine-associated receptors (TAAR) are rhodopsin-like G-protein-coupled receptors (GPCR). TAAR are involved in modulation of neuronal, cardiac and vascular functions and they are potentially linked with neurological disorders like schizophrenia and ...
Gunnar Kleinau, Juliane Pratzka, Daniela Nürnberg, Annette Grüters, Dagmar Führer-Sakel, Heiko Krude, Josef Köhrle, Torsten Schöneberg, Heike Biebermann   +8 more
doaj   +2 more sources

Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets

Biomolecules, 2023
Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are ...
Anastasia N. Vaganova, Taisiia S. Shemyakova, Karina V. Lenskaia, Roman N. Rodionov, Charlotte Steenblock, Raul R. Gainetdinov   +5 more
doaj   +3 more sources

Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats [PDF]

Frontiers in Psychiatry
IntroductionAggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain.
Ilya S. Zhukov, Ilya S. Zhukov, Yazen Alnefeesi, Natalya A. Krotova, Vsevolod V. Nemets, Konstantin A. Demin, Marina N. Karpenko, Evgeny A. Budygin, Evgeny V. Kanov, Evgeny V. Kanov, Allan V. Kalueff, Allan V. Kalueff, Allan V. Kalueff, Allan V. Kalueff, Petr D. Shabanov, Michael Bader, Natalia Alenina, Raul R. Gainetdinov, Raul R. Gainetdinov   +18 more
doaj   +2 more sources

Trace Amine-Associated Receptors’ Role in Immune System Functions

Biomedicines
Trace amines are a separate, independent group of biogenic amines, close in structure to classical monoamine neurotransmitters such as dopamine, serotonin, and norepinephrine that include many products of the endogenous or bacteria-mediated decarboxylation of amino acids. A family of G protein-coupled trace amine-associated receptors (in humans, TAAR1,
Sergey A Apryatin, Raul Gainetdinov, Vera A Apryatina   +2 more
exaly   +4 more sources