Results 21 to 30 of about 8,400 (230)
Trace amine-associated receptors at the cross-road between innate olfaction of amines, emotions, and adult neurogenesis [PDF]
Neural Regeneration Research, 2022 Evgeniya V Efimova +3 more
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Deorphanization of Olfactory Trace Amine-Associated Receptors [PDF]
The Journal of Neuroscience, 2018 Olfaction is the primary sense used by most animals to perceive the external world. The mouse olfactory system is composed of several sensory structures, the largest of which is the main olfactory epithelium (MOE). Olfactory sensory neurons (OSNs) located within the MOE detect odors and pheromones using dedicated seven-transmembrane G protein-coupled ...
Jingji, Zhang +4 more
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Trace Amines and Trace Amine-Associated Receptors: A New Frontier in Cell Signaling. [PDF]
Cell Mol Neurobiol, 2020 Trace amines, including β-phenylethylamine, p-octopamine, p-tyramine, and tryptamine, are produced in high levels in invertebrates where they play major roles in homeostasis regulation in a manner similar to that of adrenergic systems in mammals (Rutigliano et al. in Front Pharmacol 8:987, 2017; Gainetdinov et al.
Freyberg Z, Saavedra JM.
europepmc +3 more sources
Trace amine-associated receptors as emerging therapeutic targets. [PDF]
Mol Pharmacol, 2009 Endogenous trace amines (TAs) of unknown biological function are structurally related to classic monoaminergic neurotransmitters and found at low concentrations in the mammalian brain. Their recently discovered group of G protein-coupled receptors, trace amine-associated receptors (TAARs), may represent putative targets not only for trace and other ...
Sotnikova TD, Caron MG, Gainetdinov RR.
europepmc +4 more sources
Frontiers in Behavioral Neuroscience, 2022 Trace amines are a group of biogenic amines that are structurally and functionally close to classical monoamine neurotransmitters. Trace amine-associated receptors (TAARs) are emerging as promising targets for treating neuropsychiatric disorders.
Evgeniya V. Efimova +18 more
doaj +1 more source
Trace amines and their relevance to psychiatry and neurology: a brief overview
Psychiatry and Clinical Psychopharmacology, 2021 The arylalkylamines, β-phenylethylamine, m- and p-tyramine, tryptamine, m- and p-octopamine, phenylethanolamine and synephrine, have been termed trace amines because of their low absolute concentrations in the central nervous system relative to the ...
Deepak Narang +4 more
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Trace amine-associated receptors: ligands, neural circuits, and behaviors. [PDF]
Curr Opin Neurobiol, 2015 Trace amine-associated receptors (TAARs) are G Protein-Coupled Receptors that function as vertebrate olfactory receptors. Like odorant receptors, TAARs constitute an ever-evolving sensory subsystem, with individual TAARs recognizing particular chemicals and some evoking stereotyped behaviors.
Liberles SD.
europepmc +4 more sources
Expression of Trace Amine-Associated Receptors in the Grueneberg Ganglion [PDF]
Chemical Senses, 2007 The Grueneberg ganglion (GG) in the vestibule of the anterior nasal cavity is considered as an olfactory subcompartment based on expression of the olfactory marker protein (OMP) and axonal projection to the olfactory bulb. Searching for olfactory receptors present in the GG, it has been observed recently that V2r83, a member of the V2R class of ...
Joerg, Fleischer +2 more
openaire +2 more sources
Biomolecules, 2022 G protein-coupled trace amine-associated receptors (TAAR) recognize different classes of amine compounds, including trace amines or other exogenous and endogenous molecules.
Anastasia N. Vaganova +4 more
doaj +1 more source
Frontiers in Pharmacology, 2017 3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine-associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain.
Lorenza Bellusci +13 more
doaj +1 more source