Results 31 to 40 of about 8,400 (230)

Trace amine-associated receptor 1 as a monoaminergic modulator in brain [PDF]

Biochemical Pharmacology, 2009
Brain monoaminergic systems play critical roles in mood, cognition, emotion, reward, learning and attention, and aberrance in brain monoaminergic activity is associated with a variety of neuropsychiatric disorders/diseases. The present commentary focuses on trace amine-associated receptor 1 (TAAR1) and its potential regulatory roles in brain ...
Zhihua, Xie, Gregory M, Miller
openaire   +2 more sources

Natural Sympathomimetic Drugs: From Pharmacology to Toxicology

Biomolecules, 2022
Sympathomimetic agents are a group of chemical compounds that are able to activate the sympathetic nervous system either directly via adrenergic receptors or indirectly by increasing endogenous catecholamine levels or mimicking their intracellular ...
Vera Marisa Costa, Luciana Grazziotin Rossato Grando, Elisa Milandri, Jessica Nardi, Patrícia Teixeira, Přemysl Mladěnka, Fernando Remião, on behalf of The OEMONOM   +7 more
doaj   +1 more source

Non-classical amine recognition evolved in a large clade of olfactory receptors

eLife, 2015
Biogenic amines are important signaling molecules, and the structural basis for their recognition by G Protein-Coupled Receptors (GPCRs) is well understood.
Qian Li, Yaw Tachie-Baffour, Zhikai Liu, Maude W Baldwin, Andrew C Kruse, Stephen D Liberles   +5 more
doaj   +1 more source

Protein Metabolism Changes and Alterations in Behavior of Trace Amine-Associated Receptor 1 Knockout Mice Fed a High-Fructose Diet

Neurology International, 2023
Trace amines and their receptors are a family of G protein-coupled receptors widely distributed in the central nervous system and periphery. The trace amine-associated receptor 1 (TAAR1) plays a significant role as a therapeutic target for schizophrenia,
Sergey A. Apryatin, Ilya S. Zhukov, Ekaterina A. Zolotoverkhaya, Saveliy R. Kuvarzin, Temirkan A. Khunagov, Sanelya V. Ushmugina, Victor M. Klimenko   +6 more
doaj   +1 more source

Molecular basis of human trace amine-associated receptor 1 activation

Nature Communications, 2023
Abstract The human trace amine-associated receptor 1 (hTAAR1, hTA1) is a key regulator of monoaminergic neurotransmission and the actions of psychostimulants. Despite preclinical research demonstrating its tractability as a drug target, its molecular mechanisms of activation remain unclear.
Gregory Zilberg, Alexandra K. Parpounas, Audrey L. Warren, Shifan Yang, Daniel Wacker   +4 more
openaire   +4 more sources

Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes [PDF]

Journal of Neuroimmune Pharmacology, 2011
Although most research to date on Trace Amine Associated Receptor 1 (TAAR1) has focused on its role in the brain, it has been recognized since its discovery in 2001 that TAAR1 mRNA is expressed in peripheral tissues as well, suggesting that this receptor may play a role in non-neurological pathways.
Michael W, Panas, Zhihua, Xie, Helen N, Panas, Marius C, Hoener, Eric J, Vallender, Gregory M, Miller   +5 more
openaire   +2 more sources

Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics [PDF]

Biological Psychiatry, 2017
Narcolepsy, a disorder of rapid eye movement (REM) sleep, is characterized by excessive daytime sleepiness and cataplexy, a loss of muscle tone triggered by emotional stimulation. Current narcolepsy pharmacotherapeutics include controlled substances with abuse potential or drugs with undesirable side effects.
Sarah W, Black, Michael D, Schwartz, Tsui-Ming, Chen, Marius C, Hoener, Thomas S, Kilduff   +4 more
openaire   +2 more sources

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice

Scientific Reports, 2022
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain ...
Silvia Maggi, Carlotta Bon, Stefano Gustincich, Valter Tucci, Raul R. Gainetdinov, Stefano Espinoza   +5 more
doaj   +1 more source

From Food to Power: Hydrogel Thermoelectrics for Ingestible Electronics

Advanced Functional Materials, EarlyView.
We introduce a fully edible thermoelectric–electrochromic platform that harvests heat from food and converts it into a visible color change. N‐type and p‐type hydrogel thermoelectric generators connected in series power anthocyanin‐based electrochromic displays, demonstrating the feasibility of safe, biodegradable, ingestible systems for on‐food ...
Antonia Georgopoulou, Bokeon Kwak, Dario Floreano, Esther Amstad   +3 more
wiley   +1 more source