Results 41 to 50 of about 8,400 (230)
Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
Scientific Reports, 2021 Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored.
D. S. Kalinina +11 more
doaj +1 more source
Trace amine-associated receptor 1 (TAAR1) agonists
Archives of Psychiatry Research, 2022 Overview of current developments about trace amine- associated receptor 1 (TAAR1 ...
Peitl, Vjekoslav, Vlahović, Darko
openaire +3 more sources
Advanced Functional Materials, EarlyView.Optoelectronic synaptic devices based on solution‐processed molecular telluride GST‐225 phase‐change inks are demonstrated for three‐factor learning. A global optical signal broadcast through a silicon waveguide induces non‐volatile conductance updates exclusively in locally electrically flagged memristors.
Kevin Portner +14 more
wiley +1 more source
Knocking Out TAAR5: A Pathway to Enhanced Neurogenesis and Dopamine Signaling in the Striatum
CellsThe member of trace-amine associated receptor family, TAAR5 receptor was suggested to recognize tertiary amines, mostly in the olfactory system; however, knocking out the receptor TAAR5 in mice showed an enhancing effect on adult neurogenesis and ...
Anastasia N. Vaganova +7 more
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Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Central Effects of 3-Iodothyronamine Reveal a Novel Role for Mitochondrial Monoamine Oxidases
Frontiers in Endocrinology, 2018 3-Iodothyronamine (T1AM) is the last iodinated thyronamine generated from thyroid hormone alternative metabolism found circulating in rodents and in humans. So far, the physiopathological meaning of T1AM tissue levels is unknown. Much is instead known on
Annunziatina Laurino +2 more
doaj +1 more source
Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications [PDF]
Frontiers in Neuroscience, 2016 Biogenic amines are a collection of endogenous molecules that play pivotal roles as neurotransmitters and hormones. In addition to the "classical" biogenic amines resulting from decarboxylation of aromatic acids, including dopamine (DA), norepinephrine, epinephrine, serotonin (5-HT), and histamine, other biogenic amines, present at much lower ...
Pei, Yue +2 more
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Trace Amine‐Associated Receptor Intracellular Localization and Trafficking
The FASEB Journal, 2021 Trace amine‐associated receptor 1 (TAAR1) is a G‐protein coupled receptor (GPCR) found in monoaminergic neurons of the central nervous system. Amphetamine‐like psychostimulants activate TAAR1, which couples to G α s and G α 13 downstream signaling ...
Julia Huey, Aaron Janowsky
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Advanced Healthcare Materials, EarlyView.This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão +5 more
wiley +1 more source
BRET biosensors to study GPCR biology, pharmacology and signal transduction
Frontiers in Endocrinology, 2012 Bioluminescence Resonance Energy Transfer (BRET) based biosensors have been extensively used over the last decade to study protein-protein interactions and intracellular signal transduction in living cells.
Ali eSalahpour +5 more
doaj +1 more source