Results 21 to 30 of about 7,179 (272)

Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press [PDF]

, 2014
Context: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing ...
De Beer, Thomas, Peeters, Elisabeth, Remon, Jean Paul, Vervaet, Chris   +3 more
core   +1 more source

Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press

Asian Journal of Pharmaceutical Sciences, 2017
We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting ...
Takashi Osamura, Yoshiko Takeuchi, Risako Onodera, Masahiro Kitamura, Yoshiteru Takahashi, Kohei Tahara, Hirofumi Takeuchi   +6 more
doaj   +1 more source

Modeling of High-Density Compaction of Pharmaceutical Tablets Using Multi-Contact Discrete Element Method

Pharmaceutics, 2021
The purpose of this work is to simulate the powder compaction of pharmaceutical materials at the microscopic scale in order to better understand the interplay of mechanical forces between particles, and to predict their compression profiles by ...
Kostas Giannis, Carsten Schilde, Jan Henrik Finke, Arno Kwade   +3 more
doaj   +1 more source

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press [PDF]

, 2016
Context: The negative impact of magnesium stearate (MgSt) on the hardness of tablets is a well-known phenomenon, but the influence of paddle movement in the forced feeder on the lubricant effect during tablet compression is often neglected.
Peeters, Elisabeth, Remon, Jean Paul, Vanhoorne, Valérie, Vervaet, Chris   +3 more
core   +2 more sources

Comparative analysis of co-processed starches prepared by three different methods [PDF]

, 2015
Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different
Adeoye, O., Alebiowu, G., Adeoye, O., Alebiowu, G., Alakayleh, F., Rashid, I., Al-Omari, M. M. H., Al-Sou’od, K., Chowdhry, B. Z., Badwan, A. A., Alebiowu, G., Femi-Oyewo, M. N., Camargo, J. J. R., Chauhan, S. I., Nathwani, S. V., Soniwala, M. M., Chavda, J. R., Daraghmeh, N., Rashid, I., Al Omari, M. M. H., Leharne, S. A., Chowdhry, B. Z., Badwan, A., Egart, M., Ilic, I., Jankovic, B., Lah, N., Srcic, S., El-Barghouthi, M., Eftaiha, A., Rashid, I., Al-Remawi, M., Badwan, A., Gamlen, M., Gamlen, M. J. D., Martini, L. G., Al Obaidy, K. G., Ghori, M. U., Conway, B., Goyanes, A., Souto, C., Martínez-pacheco, R., Heckel, R. W., Ilić, I., Govedarica, B., Šibanc, R., Dreu, R., Srčič, S., Jivraj, M., Martini, L. G., Thomson, C. M., Joiris, E., Di Martino, P., Berneron, C., Guyot-Hermann, A., Guyot, J., Katsuno, E., Tahara, K., Takeuchi, Y., Takeuchi, H., Khomane, K. S., More, P. K., Raghavendra, G., Bansal, A. K., Kittipongpatana, O. S., Kittipongpatana, N., Mshelia, J., Apeji, Y., Olayemi, O., Nachaegari, S. K., Bansal, A. K., Nagpal, M., Goyal, A., Kumar, S., Singh, I., Odeku, O. A., Odeku, O. A., Odeku, O. A., Schmid, W., Picker-Freyer, K. M., Ogunjimi, A. T., Alebiowu, G., Ogunjimi, A. T., Alebiowu, G., Olowosulu, A. K., Oyi, A., Isah, A. B., Ibrahim, M. A., Osei-Yeboah, F., Chang, S., Sun, C. C., Osei-Yeboah, F., Sun, C. C., Patel, S., Kaushal, A. M., Bansal, A. K., Paul, S., Sun, C. C., Paul, S., Taylor, L. J., Murphy, B., Krzyzaniak, J., Dawson, N., Mullarney, M. P., Meenan, P., Sun, C. C., Pitt, K. G., Webber, R. G., Hill, K. A., Dey, D., Gamlen, M. J., Rojas, J., Buckner, I., Kumar, V., Rojas, J., Kumar, V., Saha, S., Shahiwala, A. F., Sharma, P., Modi, S. R., Bansal, A. K., Sonnergaard, J. M., Sun, C. C., Sun, C. C., Sun, C. C., Thapa, P., Lee, A. R., Choi, D. H., Jeong, S. H., Thoorens, G., Krier, F., Leclercq, B., Carlin, B., Evrard, B., Upadhyay, P., Khomane, K. S., Kumar, L., Bansal, A. K., Vanhoorne, V., Peeters, E., Snick, B. Van, Remon, J. P., Vervaet, C., Walker, E. E., Wang, S., Li, J., Lin, X., Feng, Y., Kou, X., Babu, S., Panicucci, R., Xu, M., Heng, P. W. S., Liew, C. V., Yadav, J. A., Khomane, K. S., Modi, S. R., Ugale, B., Yadav, R. N., Nagaraja, C. M., Kumar, N., Bansal, A. K.   +50 more
core   +5 more sources

Studies on tableting properties of lactose. Part III. The consolidation behaviour of sieve fractions of crystalline a-lactose\ud monohydrate [PDF]

, 1986
The consolidation and compaction behaviour of sieve fractions of crystalline α-lactose monohydrate were studied. From mercury porosimetry measurements tablet pore surface areas were derived.
Boer, A.H. de, Bolhuis, G.K., Bosch, H., Kussendrager, K.D., Lerk, C.F., Vromans, H.   +5 more
core   +3 more sources

Powder Technology and Pharmaceutical Development: Particle Size and Particle Adhesion

KONA Powder and Particle Journal, 2013
Both the FDA (U.S. Food and Drug Administration) and ICH (International Conference on Harmonisation) have urged the incorporation of Quality by Design (QbD)1) into the manufacture of pharmaceutical products2).The performance of many pharmaceutical ...
Frank M. Etzler, Mohammad Nasir Uddin
doaj   +1 more source

Opposing Effects of Additives in Dry Milling and Tableting of Organic Particles

Pharmaceutics, 2021
Applying additives and excipients during the dry processing of fine particles is a common measure to control the particle–particle interactions, to specifically influence the powder properties and to enhance the process efficiency or product quality.
Lina Miethke, Paul Prziwara, Jan Henrik Finke, Sandra Breitung-Faes   +3 more
doaj   +1 more source

3D Simulation of Internal Tablet Strength During Tableting [PDF]

AAPS PharmSciTech, 2011
This study presents a new approach to model powder compression during tableting. The purpose of this study is to introduce a new discrete element simulation model for particle-particle bond formation during tablet compression. This model served as the basis for calculating tablet strength distribution during a compression cycle.
Simo Matti, Siiriä, Osmo, Antikainen, Jyrki, Heinämäki, Jouko, Yliruusi   +3 more
openaire   +2 more sources

Impact of Powder Properties on the Rheological Behavior of Excipients

Pharmaceutics, 2021
With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies. Many flow characterization techniques are present,
Pauline H. M. Janssen, Sébastien Depaifve, Aurélien Neveu, Filip Francqui, Bastiaan H. J. Dickhoff   +4 more
doaj   +1 more source