Results 101 to 110 of about 76,984 (297)

Invasive Aspergillosis in Mice Immunosuppressed with Cyclosporin A, Tacrolimus (FK506), or Sirolimus (Rapamycin) [PDF]

, 1997
Kevin P. High, Ronald G. Washburn
openalex   +1 more source

Dupilumab and Systemic Hematologic Malignancies: Case Series and Literature Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting 15%–20% of children and 3%–10% of adults. An increased risk of systemic lymphomas – but not leukemias – has been reported in patients with AD. Dupilumab, a monoclonal IgG4 antibody targeting IL‐4 and IL‐13 signaling, is approved for moderate‐to‐severe AD and is ...
Nello Tommasino, Cataldo Patruno, Francesca di Vico, Maddalena Napolitano   +3 more
wiley   +1 more source

Successful Treatment of Coexisting Alopecia Areata and Bullous Pemphigoid With Dupilumab: A Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Alopecia areata (AA) and bullous pemphigoid (BP) are distinct autoimmune diseases, but growing evidence points to overlapping immune pathways. We present a rare case of a 71‐year‐old woman with concurrent AA and BP. She initially presented with 10 months of progressive scalp and body hair loss (Severity of Alopecia Tool [SALT] ~ 80) and nail ...
Anna Brinks, Carli Needle, Caitlin Kearney, Prince Adotama, Kenneth Grossman, Jerry Shapiro, Kristen Lo Sicco   +6 more
wiley   +1 more source

Drug–drug interaction between tacrolimus and caspofungin in Chinese kidney transplant patients with different genotypes

Therapeutic Advances in Drug Safety
Background: The effect of drug–drug interaction between tacrolimus and caspofungin on the pharmacokinetics of tacrolimus in different CYP3A5 genotypes has not been reported in previous studies.
Yundi Zhang, Bowen Shen, Yue Li, Huiying Zong, Xiaoming Zhang, Xiaohong Cao, Fengxi Liu, Yan Li   +7 more
doaj   +1 more source

In vitro assessment of the risk of ABCB1-mediated drug–drug interaction between rivaroxaban and tacrolimus in human embryonic kidney 293 recombinant cell lines

Research and Practice in Thrombosis and Haemostasis
Background: In lung transplant patients, direct oral anticoagulants are often taken in combination with immunosuppressive drugs such as tacrolimus. Since tacrolimus is a substrate and inhibitor of the efflux protein ABCB1, also transporting direct oral ...
Gwenaëlle Mahieu, Anne-Laure Sennesael, Lionel Pochet, Vincent Haufroid, Françoise Van Bambeke, Anne Spinewine, Laure Elens   +6 more
doaj   +1 more source

Characteristics of Adult Patients With Atopic Dermatitis Initiating Biologics and Janus Kinase Inhibitors in the CorEvitas Atopic Dermatitis Registry

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Biologics and Janus kinase inhibitors (JAKi) are two advanced systemic treatment options for patients with atopic dermatitis (AD). The decision to initiate one of these therapies is complex and may be driven by many factors.
Eric L. Simpson, Linda Stein Gold, Seemal R. Desai, Alexandra K. Golant, Douglas DiRuggiero, Christian Fenske, Yolanda Muñoz Maldonado, Alvin H. Li, Zach Dawson, Kaylee Ho, Kayla Callahan, Gaia Gallo, Jonathan I. Silverberg   +12 more
wiley   +1 more source

Improvement of Dupilumab‐Induced Psoriasiform Eruption Following a Switch to Tralokinumab

JEADV Clinical Practice, EarlyView.
ABSTRACT Biologic therapies have transformed the management of atopic dermatitis (AD) and prurigo nodularis (PN), yet paradoxical adverse events such as dupilumab‐induced psoriasiform eruption (DPE) are increasingly recognized. We report a 48‐year‐old Japanese man with long‐standing AD and PN who developed scaly, erythematous plaques on the elbows ...
Masato Mizuashi, Yoshinori Sasaki
wiley   +1 more source

Tacrolimus treatment in women with repeated implantation failures

Reproductive Medicine and Biology
Background Tacrolimus is an immunosuppressive drug that works as a calcineurin inhibitor to improve the reproductive outcomes for women who have experienced multiple implantation failures (RIF) and show elevated type 1 helper T (Th1)/Th2 cell ratios ...
Koji Nakagawa, Rikikazu Sugiyama
doaj   +1 more source

Clinical and Histopathologic Examination of Renal Allografts Treated with Tacrolimus (FK506) for at Least One Year [PDF]

, 1998
Motoaki Hatori, S Takahara, Masahiro Kyo, Y Kokado, S Nagano, Äkïhïko Okuyama   +5 more
openalex   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source