Results 81 to 90 of about 105,726 (291)

Therapeutic potential of coenzyme Q10 in mitochondrial dysfunction during tacrolimus-induced beta cell injury

Scientific Reports, 2019
We previously reported that oxidative stress induced by long-term tacrolimus treatment impairs mitochondrial function in pancreatic beta cells. In this study, we aimed to investigate the therapeutic potential of coenzyme Q10, which is known to be a ...
K. Luo, Ji Hyun Yu, Yi Quan, Y. Shin, K. Lee, H. Kim, E. Ko, B. Chung, S. Lim, Chul-woo Yang   +9 more
semanticscholar   +1 more source

Supratherapeutic drug concentration triggers: A novel data‐driven approach to assess their value for medication safety surveillance in intensive care

British Journal of Clinical Pharmacology, EarlyView.
Aims Electronic triggers (e‐triggers) are used as screening signals to detect potential adverse drug events (ADEs) and offer an effective system level approach for medication safety surveillance. Their clinical utility is typically evaluated through time‐consuming manual chart review by experts, limiting implementation.
Anne Paulien Langermans, Izak A. R. Yasrebi‐de Kom, Dylan Wayne de Lange, Nicolette Fransisca de Keizer, Joanna E. Klopotowska, on behalf of the RESCUE Study group, C. S. C. Bouman, E. N. van Roon, P. F. Schutte, J. ten Cate, D. van Balen, S. Hendriks, C. Lau, W. J. Vermeijden, A. Beishuizen, J. B. Masselink, P. E. Spronk, H. J. M. van Kan, P. W. de Feiter, E. J. Wils, A. Wieringa, A. J. Valkenburg, W. M. van den Bergh, M. H. Renes, W. Bult, E. de Jonge, M. Hoeksema, E. J. Wesselink, I. M. Purmer, B. E. Bosma, S. H. W. van Bree, H. J. W. Lammers, R. J. Bosman, E. J. F. Franssen, A. Karakus, M. Sigtermans, E. M. Kuck, D. A. Dongelmans, M. J. H. Aries, E. V. Uijtendaal, M. C. Reuland   +40 more
wiley   +1 more source

Individualized dosing parameters for tacrolimus in the presence of voriconazole: a real-world PopPK study

Frontiers in Pharmacology
ObjectivesSignificant increase in tacrolimus exposure was observed during co-administration with voriconazole, and no population pharmacokinetic model exists for tacrolimus in renal transplant recipients receiving voriconazole.
Yi-Chang Zhao, Yi-Chang Zhao, Zhi-Hua Sun, Zhi-Hua Sun, Jia-Kai Li, Jia-Kai Li, Huai-Yuan Liu, Huai-Yuan Liu, Bi-Kui Zhang, Bi-Kui Zhang, Xu-Biao Xie, Chun-Hua Fang, Indy Sandaradura, Indy Sandaradura, Feng-Hua Peng, Miao Yan, Miao Yan   +16 more
doaj   +1 more source

Lactobacillus fermentum Improves Tacrolimus‐Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling

Molecular Nutrition & Food Research, 2018
SCOPE The aim is to analyze whether the probiotic Lactobacillus fermentum CECT5716 (LC40) can prevent endothelial dysfunction and hypertension induced by tacrolimus in mice.
M. Toral, M. Romero, A. Rodríguez‐Nogales, R. Jiménez, Iñaki Robles-Vera, Francesca Algieri, N. Chueca-Porcuna, M. Sánchez, Néstor de la Visitación, M. Olivares, Federico García, F. Pérez-Vizcaino, J. Gálvez, J. Duarte   +13 more
semanticscholar   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Tacrolimus [PDF]

Reactions Weekly, 2020
  +4 more sources

Immunosuppressive effect of the gut microbiome altered by high‐dose tacrolimus in mice

American Journal of Transplantation, 2018
The alterations induced in gut microbiota by tacrolimus may affect immune function and organ transplantation. Mice were treated with high‐dose tacrolimus for 14 days. The fecal microbiota were analyzed by pyrosequencing the 16S rRNA genes, and the effect
Zijian Zhang, L. Liu, Hao Tang, W. Jiao, S. Zeng, Yue Xu, Q. Zhang, Zhaoli Sun, A. K. Mukherjee, X. Zhang, Xiaopeng Hu   +10 more
semanticscholar   +1 more source

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari, Ruud H. J. Verstegen, Cintia Cruz, Erin Chung, Aleena Azim, Shinya Ito, Tamorah R. Lewis   +6 more
wiley   +1 more source

Safety and Efficacy of Infusional Perioperative Tacrolimus Therapy in Crohn’s Disease Patients Undergoing Intestinal Resection

Inflammatory Intestinal Diseases
Introduction: Perioperative optimization of Crohn’s disease (CD) patients is mandatory in order to ensure favorable outcomes and limit perioperative morbidity such as anastomosis-related complications.
Maximilian Beck, Niklas Schomburg, Max Albers, Detlef Bartsch, Niklas Knapp, Jan Granseyer, Thomas Gress, Christian Bauer   +7 more
doaj   +1 more source

Results of ASERTAA, a Randomized Prospective Crossover Pharmacogenetic Study of Immediate-Release Versus Extended-Release Tacrolimus in African American Kidney Transplant Recipients.

American Journal of Kidney Diseases, 2018
BACKGROUND Differences in tacrolimus dosing across ancestries is partly attributable to polymorphisms in CYP3A5 genes that encode tacrolimus-metabolizing cytochrome P450 3A5 enzymes.
J. Trofe‐Clark, D. Brennan, P. West-Thielke, M. Milone, M. Lim, R. Neubauer, V. Nigro, R. Bloom   +7 more
semanticscholar   +1 more source