Results 31 to 40 of about 76,984 (297)

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Hemoglobin and total bilirubin may affect tacrolimus clearance in liver transplant patient following the early postoperative period: a case report

Journal of Medical Case Reports
Background Tacrolimus is a potent calcineurin inhibitor (CNI) that is principally used as a first-line immunosuppressant for the prophylaxis of allograft rejection in liver transplantation (LT) patients.
Vichapat Tharanon, Pansa Iamrahong, Jutamas Tuamsem, Kunvadee Choochaeam, Titinun Auamnoy, Abhasnee Sobhonslidsuk   +5 more
doaj   +1 more source

Advancements in Dissolving Microneedles for Effective Transdermal Delivery in Rheumatoid Arthritis Treatment

Advanced Materials Interfaces, EarlyView.
Rheumatoid arthritis, a chronic inflammatory joint disease, faces limitations with conventional therapies. Dissolving microneedles (DMNs) enable biocompatible, high‐capacity transdermal drug delivery. However, skin elasticity challenges their strength, limiting drug release depth.
Wangrui Peng, MeeiChyn Goh, Jie Lan, Meng Du, Zhiyi Chen   +4 more
wiley   +1 more source

The level of intracellular tacrolimus in T cell is affected by CD44 ABCB1 activities triggered by inflammation

European Journal of Inflammation, 2019
Rejection is an important issue in kidney transplant. Although with adequate trough level of tacrolimus, acute rejection occurs, and we are focused on these cases.
Eunjin Bae, Seung Seok Han, Dong Jun Park, Hajeong Lee, Mi-Yeon Yu, Kyu Hong Kim, Min Chang Kim, Joo-Youn Cho, Sang-Il Min, Jongwon Ha, Yon Su Kim, Seung Hee Yang   +11 more
doaj   +1 more source

Ultrasensitive Detection of FKBP12 Using a Synthetic Receptor‐Functionalized QCM Nanoplatform

Advanced Sensor Research, EarlyView.
A reusable nanosensor platform for ultralow FKBP12 detection in physiological fluids is presented. Combining a gold‐coated QCM with a custom‐designed receptor in a self‐assembled monolayer, the device achieves picomolar sensitivity and high selectivity.
Martina Tozzetti, Maria Raffaella Martina, Giacomo Lucchesi, Kristian Vasa, Ahtsham Ishaq, Laura Marsili, Piero Procacci, Stefano Menichetti, Gabriella Caminati   +8 more
wiley   +1 more source

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Tacrolimus‐Related Neurotoxicity of the Pons in Children: Review of the Literature and a Case Report

Annals of the Child Neurology Society
Introduction Tacrolimus is a potent immunosuppressive agent effective in preventing solid organ transplant rejection. It is widely used following allogeneic liver, kidney, heart, and bone marrow transplantation.
Amy Hill, Mohamed Bilal Haradwala, Jean‐Baptiste Le Pichon   +2 more
doaj   +1 more source

The Association of Tacrolimus Formulation on Cerebral Blood Flow and Cognitive Function

Transplantation Direct, 2023
Background. Calcineurin inhibitors are inherent vasoconstrictors. Cerebral vasoconstriction can reduce cerebral blood flow (CBF), and negatively impact cerebrovascular response (CVR) to exercise, and cognitive function.
Irisa Mahaparn, MD, Rebecca J. Lepping, PhD, Robert N. Montgomery, PhD, Rishav Mukherjee, MSc, Sandra A. Billinger, PhD, William M. Brooks, PhD, Aditi Gupta, MD   +6 more
doaj   +1 more source

A new immunosuppressant: tacrolimus [PDF]

Postgraduate Medical Journal, 1996
Summary Tacrolimus is the new name for the Japanese immunosuppressant drug FK506. It blocks interleukin 2 transcription thereby inhibiting the CD4 Th-1 lymphocyte response to foreign antigens. It also selectively inhibits cytokine secretion of IL3, IL4 and interferon-gamma. It is metabolised by the cytochrome P-450 enzyme system.
openaire   +3 more sources

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source