Results 71 to 80 of about 15,576 (197)

Adulteration of Dietary Supplements by the Illegal Addition of Synthetic Drugs: a review [PDF]

, 2016
In the last few years, the consumption of dietary supplements, especially those having plants as ingredients, has been increasing due to the common idea that they are natural products posing no risks to human health.
Amaral, Joana S., Oliveira, Beatriz, Rocha, Tiago   +2 more
core   +1 more source

Glymphatic System Dysfunction in Central Nervous System Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Glymphatic Dysfunction in Neurological Disorders: The glymphatic system is a brain‐wide clearance system that removes neurotoxic waste via AQP4‐mediated CSF‐ISF exchange. Dysfunction through AQP4 mislocalization, BBB injury, and inflammation annihilates clearance and causes acute (stroke, TBI) and chronic disease.
Anwar Zahran, Omar Abu‐Khazneh, Mohammad Bdair, Orabi Hajjeh, Mohammed AbuBaha, Waseem Shehadeh, Ameer Awashra, Ibrahim Alazizi, Raya Fuqha, Sakeena Saife, Hasan Fuqha, Fathi Milhem, Husam Hamshary, Dana Abuzahra, Umar Shuaib   +14 more
wiley   +1 more source

Tadalafil for Treatment of Fetal Growth Restriction: A Review of Experimental and Clinical Studies

Biomedicines
Fetal growth restriction (FGR) is a major concern in perinatal care. Various medications have been proposed as potential treatments for this serious condition. Nonetheless, there is still no definitive treatment. We studied tadalafil, a phosphodiesterase-
Shintaro Maki, Sho Takakura, Makoto Tsuji, Shoichi Magawa, Yuya Tamaishi, Masafumi Nii, Michiko Kaneda, Kenta Yoshida, Kuniaki Toriyabe, Eiji Kondo, Tomoaki Ikeda   +10 more
doaj   +1 more source

Inibidores da 5-fosfodiesterase no tratamento sintomático da hiperplasia benigna da próstata [PDF]

, 2011
Trabalho final de mestrado integrado em Medicina, área científica de Urologia, apresentado á Faculdade de Medicina da Universidade de CoimbraTanto a hiperplasia benigna da próstata como a disfunção eréctil são patologias com elevada prevalência em ...
Costa, Christine Silva
core  

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity [PDF]

, 2014
STUDY QUESTION: Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions?
Alasmari, Alasmari, Baker, Barratt, Baxendale, Bjorndahl, Christopher L.R. Barratt, Comhaire, Conti, Cooper, David, Fisch, Ford, Francis, Glenn, Harrison, HFEA, Horvath, Houslay, Huacuja, Hull, Hunnicutt, Irvine, Ivic, Lefièvre, Lefièvre, Lefièvre, Linda Lefièvre, Lorna Frame, Martin, Mortimer, Mrsny, Nassar, Negri, O'Connell, Oladipo A. Madamidola, Paul G. Wyatt, Publicover, Richter, Sarah J. Martins Da Silva, Sean G. Brown, Sousa, Steve Tardif, Stone, Tesarik, Tomlinson, Tomlinson, Torres-Flores, Tournaye, Tournaye, Van der Steeg, Wang, Yang, Yovich, Yovich   +54 more
core   +5 more sources

Photoisomerization in Cyclic Dipeptide Derivatives: Photoswitchable Supramolecular Hydrogels and the Discovery of Hemipiperazine Photoswitches

ChemPhotoChem, Volume 10, Issue 3, March 2026.
Photoswitchable cyclic dipeptides (CDPs) can be used to prepare hydrogels that reversibly dissipate upon irradiation, or to photomodulate the development of living organisms. We report here applications and perspectives for CDPs containing azobenzene photoswitches or newly discovered hemipiperazine photoswitches in smart materials and biological ...
Zbigniew L. Pianowski
wiley   +1 more source

Tadalafil [PDF]

pharma-kritik, 2005
Ein lang wirkender Phosphodiesterasehemmer zur Behandlung der erektilen Dysfunktion.
openaire   +2 more sources

Impact of tadalafil on cardiovascular and organ dysfunction induced by experimental sepsis [PDF]

Acute and Critical Care
Background Sepsis is a life-threatening condition that affects the cardiovascular and renal systems. Severe hypotension during sepsis compromises tissue perfusion, which can lead to multiple organ dysfunction and death.
Marcelo Almeida Nakashima, Gabrielle Delfrate, Lucas Braga Albino, Gustavo Ferreira Alves, Junior Garcia Oliveira, Daniel Fernandes   +5 more
doaj   +1 more source

Enhancing cognition before clinical symptoms of dementia. [PDF]

, 2015
As the title of the special issue indicates, controversy surrounds augmentation of brain cognition in humans. Lacking efficacious drugs for Alzheimer's disease (AD) and with many AD patients recruited for clinical trials that unfortunately do not provide
Franco Fernández, Rafael
core   +2 more sources

Future Prospects of Imatinib in Advanced Pulmonary Hypertension Management

IUBMB Life, Volume 78, Issue 3, March 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a severe, progressive disease characterized by elevated pulmonary arterial pressure and increased vascular resistance. This hemodynamic strain forces the right ventricle to pump against a high‐pressure system, ultimately leading to right‐sided heart failure and death.
Federica Davì, Stella Mangione, Antonella Iaconis, Tiziana Genovese, Nicla Tranchida, Salvatore Cuzzocrea   +5 more
wiley   +1 more source