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TADs as the Caller Calls Them

Journal of Molecular Biology, 2020
Developments in proximity ligation methods and sequencing technologies have provided high-resolution views of the organization of the genome inside the nucleus. A prominent feature of Hi-C maps is regions of increased self-interaction called topologically associating domains (TADs).
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TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

2023
ABSTRACT Topological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely unknown.
Mariam, Okhovat   +24 more
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A “Tad” of Science Appreciation

Early Childhood Education Journal, 2006
One year, when we were living in Alabama, I grew watermelons in the backyard garden. I tied the vines to the wooden fence and the watermelon fruits hung down from them—so perfectly ellipsoidal and smooth! It was such a pleasure to see their symmetrical shape with even, green coloring and distinct black markings,—no yellow or brown spots like ground ...
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CDC weighs in on TADs

American Journal of Orthodontics and Dentofacial Orthopedics, 2009
Jennifer L, Cleveland, William, Kohn
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TAD, a misnomer?

American Journal of Orthodontics and Dentofacial Orthopedics, 2009
HyeRan, Choo   +2 more
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BINDER achieves accurate identification of hierarchical TADs by comprehensively characterizing consensus TAD boundaries

Genome Research
As crucial chromatin structures, hierarchical TADs play important roles in epigenetic organization, transcriptional activity, gene regulation, and cell differentiation. Currently, it remains a highly challenging task to accurately identify hierarchical TADs in a computational manner. The key bottleneck for existing TAD callers lies in the difficulty in
Yangyang, Liu   +2 more
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TAD Case-Tool

2001
This final chapter introduces the TAD case-tool. This software implements most of the algorithms of TAD methodology described in the previous chapters. The purpose of developing such a case-tool is to support the use of the methodology and to enable the reader to test the ideas and concepts of the methodology explained in different phases and steps.
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TADs: Dynamic structures to create stable regulatory functions

Current Opinion in Structural Biology, 2023
Daan Noordermeer
exaly  

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