Results 171 to 180 of about 13,596 (270)

Integrating heterogeneity into topologically associating domain boundary prediction in large genomic context in human. [PDF]

NAR Genom Bioinform
Sun Y, Jensen LJ, Tommerup N, Gorodkin J.   +3 more
europepmc   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses of Savolitinib Alone or in Combination With Osimertinib in Patients With Locally Advanced or Metastatic Solid Tumors

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Savolitinib (ORPATHYS) is an oral, highly selective inhibitor of the mesenchymal–epithelial transition (MET) receptor tyrosine kinase that has demonstrated clinical activity across multiple advanced solid tumors. A comprehensive population pharmacokinetics analysis using cumulative data from 998 patients across 10 clinical studies ...
Azar Shahraz, Thibaud Derippe, Kiran Kumar Kode, Jessica Allmond, Simon Nelson, Ike Igwegbe, Aarti Sawant‐Basak, Karthick Vishwanathan, Kowser Miah   +8 more
wiley   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, Volume 293, Issue 17, Page 5149-5169, September 2026.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Temporary Anchorage Devices and Clear Aligner Therapy: A Systematic Review. [PDF]

Cureus
Sawady M, Dhayihi FA, Al Dira MS, Arishi LM, Moafa NE, Abbas AM, Rajhi AY, Abbas TS, Madkhali RH, Jali GG.   +9 more
europepmc   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, Volume 293, Issue 17, Page 5340-5362, September 2026.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma. [PDF]

Elife
Bayanjargal A, Taslim C, Showpnil IA, Selich-Anderson J, Crow JC, Zhou R, Lessnick SL, Theisen ER.   +7 more
europepmc   +1 more source

A quantitative dissection of the DNA‐binding properties of pathogenic GATA1 mutants

The FEBS Journal, Volume 293, Issue 17, Page 5140-5144, September 2026.
Transcription factor activity is influenced by cell context, accessibility of target sequences, and co‐factor recruitment. Quantitatively characterizing the consequences of individual mutations in the transcription factors or their target sequences remains technically challenging. Zambo et al. use mutant GATA1‐ATP2B4 binding to illustrate an innovation
Kaoru Takasaki
wiley   +1 more source

Tavistock Adult Depression Study (TADS) [PDF]

, 2017
Taylor, David, McPherson, Susan, Fonagy, Peter, Rost, Felicitas   +3 more
core   +3 more sources

A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation. [PDF]

Science
Cheng Y, Wang J, Zhang Y, Yadavalli AD, Liu M, Jin S, Buddle G, Haberman A, Schatz DG, Wang S.   +9 more
europepmc   +1 more source

Dolutegravir population pharmacokinetics in racially, sex‐ and age‐diverse and antiretroviral therapy‐experienced adults with HIV in the United States

HIV Medicine, Volume 27, Issue 9, Page 1517-1529, September 2026.
Abstract Objectives Dolutegravir (DTG) has been associated with weight gain in women with HIV, Black people with HIV and people with HIV60 years. This study aimed to characterise DTG population pharmacokinetics (PopPK) in a diverse population including these sub‐populations.
Adrian Khoei, Andrew Edmonds, Yen Chang, Catalina Ramirez, Mackenzie Vogan, Amanda Poliseno, Steven Wolinsky, Ken Ho, Todd T. Brown, Joseph B. Margolick, Jacquett Batson, Jennifer Hoffmann, Mark A. Marzinke, Mirjam‐Colette Kempf, Maria L. Alcaide, Joffi Effoe, Cecile D. Lahiri, Igho Ofotokun, Anandi N. Sheth, Stephen Gange, Audrey L. French, Bani Tamraz, Bradley E. Aouizerat, Phyllis C. Tien, Seble G. Kassaye, Jack DeHovitz, Kathryn Anastos, Kara W. Chew, Michelle Floris‐Moore, Julie B. Dumond   +29 more
wiley   +1 more source