Results 91 to 100 of about 2,943 (200)

Improved genetic screening with zygosity detection through multiplex high‐resolution melting curve analysis and biochemical characterisation for G6PD deficiency

Tropical Medicine &International Health, Volume 30, Issue 5, Page 437-457, May 2025.
Abstract Accurate diagnosis of glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is crucial for relapse malaria treatment using 8‐aminoquinolines (primaquine and tafenoquine), which can trigger haemolytic anaemia in G6PD‐deficient individuals. This is particularly important in regions where the prevalence of G6PD deficiency exceeds 3%–5%, including ...
Usa Boonyuen, Beatriz Aira C. Jacob, Kamonwan Chamchoy, Natnicha Pengsuk, Sirinyatorn Talukam, Chanya Petcharat, Emily R. Adams, Thomas Edwards, Kobporn Boonnak, Syazwani Itri Amran, Nurriza Ab Latif, Naveen Eugene Louis   +11 more
wiley   +1 more source

Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data [PDF]

, 2016
BACKGROUND: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite
Bassat Orellana, Quique, González, Raquel, Menéndez, Clara, WWARN Gametocyte Study Group   +3 more
core   +4 more sources

Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.

PLoS Neglected Tropical Diseases, 2022
BackgroundPrimaquine and tafenoquine are the only licensed drugs that effectively kill the hypnozoite stage and are used to prevent Plasmodium vivax malaria relapse.
Kamonwan Chamchoy, Sirapapha Sudsumrit, Thanyapit Thita, Srivicha Krudsood, Rapatbhorn Patrapuvich, Usa Boonyuen   +5 more
doaj   +1 more source

Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum [PDF]

, 2016
© 2015, Springer-Verlag Berlin Heidelberg. The present study aimed to investigate the in vitro antileishmanial activity of strychnobiflavone flavonoid against Leishmania infantum, as well as its mechanism of action, and evaluate the ex vivo ...
Coelho, Eduardo A. F., Lage, Paula S., Soto, Manuel   +2 more
core   +1 more source

Tafenoquine: A 2018 Novel FDA-Approved Prodrug for the Radical Cure of Plasmodium vivax Malaria and Prophylaxis of Malaria

Pharmaceuticals, 2019
Tafenoquine (an 8-aminoquinoline) was approved by the Food and Drug Administration (FDA) in 2018 for the radical cure of Plasmodium vivax malaria and preventive action against malaria.
Annie Mayence, Jean Jacques Vanden Eynde   +1 more
doaj   +1 more source

Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children [PDF]

, 2017
Low-dose primaquine is recommended to prevent Plasmodium falciparum malaria transmission in areas threatened by artemisinin resistance and areas aiming for malaria elimination.
Bousema, Teun, Drakeley, Chris, Goncalves, Bronner P., Murry, Daryl, Niemi, Mikko, Pett, Helmi, Sirima, Sodiomon B., ter Heine, Rob, Tiono, Alfred B.   +8 more
core   +2 more sources

Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis.

PLoS Neglected Tropical Diseases, 2023
IntroductionScreening for G6PD deficiency can inform disease management including malaria. Treatment with the antimalarial drugs primaquine and tafenoquine can be guided by point-of-care testing for G6PD deficiency.Methods and findingsData from similar ...
Wondimagegn Adissu, Marcelo Brito, Eduardo Garbin, Marcela Macedo, Wuelton Monteiro, Sandip Kumar Mukherjee, Jane Myburg, Mohammad Shafiul Alam, Germana Bancone, Pooja Bansil, Sampa Pal, Abhijit Sharma, Stephanie Zobrist, Andrew Bryan, Cindy S Chu, Santasabuj Das, Gonzalo J Domingo, Amanda Hann, James Kublin, Marcus V G Lacerda, Mark Layton, Benedikt Ley, Sean C Murphy, Francois Nosten, Dhélio Pereira, Ric N Price, Arunansu Talukdar, Daniel Yilma, Emily Gerth-Guyette   +28 more
doaj   +1 more source

Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases

Journal of Extracellular Vesicles, Volume 13, Issue 8, August 2024.
Abstract Parasitic diseases have a significant impact on human and animal health, representing a major hazard to the public and causing economic and health damage worldwide. Extracellular vesicles (EVs) have long been recognized as diagnostic and therapeutic tools but are now also known to be implicated in the natural history of parasitic diseases and ...
Ana Acacia Sá Pinheiro, Ana Claudia Torrecilhas, Bruno Solano de Freitas Souza, Fernanda Ferreira Cruz, Herbert Leonel de Matos Guedes, Tadeu Diniz Ramos, Miqueias Lopes‐Pacheco, Celso Caruso‐Neves, Patricia R. M. Rocco   +8 more
wiley   +1 more source

Antimalarial activity of the anticancer histone deacetylase inhibitor SB939 [PDF]

, 2012
Histone deacetylase (HDAC) enzymes posttranslationally modify lysines on histone and nonhistone proteins and play crucial roles in epigenetic regulation and other important cellular processes. HDAC inhibitors (e.g., suberoylanilide hydroxamic acid [SAHA;
Andrews, Katherine T., Do, Tram Anh, Fairlie, David P., Goodman, Christopher D., Haque, Ashraful, Lucke, Andrew J., McFadden, Geoffrey I., Sahama, Ishani, Skinner-Adams, Tina, Sumanadasa, Subathdrage D. M.   +9 more
core   +1 more source

Pharmacokinetic Models of Tafenoquine: Insights for Optimal Malaria Treatment Strategies

Pharmaceutics
Tafenoquine (TQ) is a new 8-aminoquinoline antimalarial drug developed by the US Army for Plasmodium vivax malaria treatment. Modeling and simulation are essential tools for drug development and improving rationality in pharmacotherapy, and different ...
Luisa Oliveira Santos, Izabel Almeida Alves, Francine Johansson Azeredo   +2 more
doaj   +1 more source