Results 81 to 90 of about 2,943 (200)

Enantiomeric resolution of primaquine, quinacrine and tafenoquine antibacterial medicines using ristocetin macrocyclic glycopeptide antibiotics CSP

Journal of Taibah University for Science, 2020
The enantiomeric resolution of primaquine, quinacrine and tafenoquine antibacterial medicines is described on Chirobiotc R column (150 ×4.6 mm, 5.0 µm). Two eluents used were methanol–acetonitrile-water-triethyl amine in the ratio of 70:10:20:0.1 (I) and
Zeid A. ALOthman, Abdullah G. ALanazi, Imran Ali   +2 more
doaj   +1 more source

Towards Malaria Elimination: A Nationwide Case–Control Study to Assess Risk Factors for Severe Malaria‐Related Deaths in Brazil

Tropical Medicine &International Health, Volume 30, Issue 11, Page 1194-1210, November 2025.
ABSTRACT Objective The objective of this study is to describe malaria‐related deaths and assess their risk factors. Methods This is a case–control study using data from Brazil's Ministry of Health (2011–2020) on malaria‐related deaths (ICD‐10: B50‐B54). A probabilistic record linkage was performed to match epidemiological data (Sivep‐Malaria and Sinan)
Klauss K. S. Garcia, Gabriel Z. Laporta, Elisabeth Carmen Duarte, Seyi Soremekun, Amanda Amaral Abrahão, Anderson Coutinho da Silva, Anielle de Pina Costa, Marcus Vinícius Guimarães Lacerda, Chris Drakeley, Walter Massa Ramalho, André M. Siqueira   +10 more
wiley   +1 more source

Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: A cost-effectiveness analysis using a transmission model.

PLoS Medicine
BackgroundMalaria transmission modelling has demonstrated the potential impact of semiquantitative glucose-6-phosphate dehydrogenase (G6PD) testing and treatment with single-dose tafenoquine for Plasmodium vivax radical cure but has not investigated the ...
David J Price, Narimane Nekkab, Wuelton M Monteiro, Daniel A M Villela, Julie A Simpson, Marcus V G Lacerda, Michael T White, Angela Devine   +7 more
doaj   +1 more source

Genotype-phenotype association and biochemical analyses of glucose-6-phosphate dehydrogenase variants: Implications for the hemolytic risk of using 8-aminoquinolines for radical cure

Frontiers in Pharmacology, 2022
Background:Plasmodium vivax remains the malaria species posing a major threat to human health worldwide owing to its relapse mechanism. Currently, the only drugs of choice for radical cure are the 8-aminoquinolines (primaquine and tafenoquine), which are
Sirapapha Sudsumrit, Kamonwan Chamchoy, Duantida Songdej, Poom Adisakwattana, Srivicha Krudsood, Emily R. Adams, Mallika Imwong, Ubolsree Leartsakulpanich, Usa Boonyuen   +8 more
doaj   +1 more source

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, Volume 89, Issue 5, Page 384-397, September 2025.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group. [PDF]

, 2018
The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the ...
Ahmed, Rukhsana, Aktaruzzaman, MM, Alam, Mohammad Shafiul, Anstey, Nick M, Ashley, Elizabeth, Awasthi, Kiran Raj, Baird, J Kevin, Bardaji, Azucena, Battle, Katherine E, Bell, David, Boaz, Leonard, Bobogare, Albino, Burdam, Faustina Helen, Chandramohan, Daniel, Cheng, Qin, Chindawongsa, Keobouphaphone, Culpepper, Janice, Das, Santasabuj, Deray, Raffy, Desai, Meghna, Devine, Angela, Domingo, Gonzalo, Duc, Thang Ngo, Duoquan, Wang, Duparc, Stephan, Dysoley, Lek, Floranita, Rustini, Gerth-Guyette, Emily, Ghimire, Prakash, Grietens, Koen Peeters, Gryseels, Charlotte, Gudo, Clarice Samo, Hawley, Bill, Hermawan, Lukas, Howes, Rosalind E, Hugo, Cecilia, Huy, Tho Tran, Hwang, Jimee, Jagoe, George, Jambert, Elodie, Jaya, Indra, Jhora, Sanya Tahmina, Jinwei, Wu, Karunajeewa, Harin, Kenangalem, Enny, Khan, Wasif Ali, Lacerda, Marcus, Laihad, Ferdinand, Lal, Bibek Kumar, Landuwulang, Chandra, Le Perru, Emmanuel, Lee, Sang-Eun, Ley, Benedikt, Makita, Leo Sora, Marfurt, Jutta, McCarthy, James, Mekuria, Asrat, Mishra, Neelima, Mudin, Rose Nani Binti, Naket, Esau, Nambanya, Simone, Nausien, Johnny, Noviyanti, Rinitis, Nowak, Spike, Pasaribu, Ayodhia Pitaloka, Pfeffer, Daniel, Poespoprodjo, Jeanne Rini, Price, Ric N, Qi, Gao, Rahmalia, Annisa, Rogerson, Stephen, Samad, Iriani, Sariwati, Elvieda, Sattabongkot, Jetsumon, Satyagraha, Ari, Shanks, Dennis, Sharma, Surender Nath, Sibley, Carol Hopkins, Sumiwi, Maria Endang, Sungkar, Ali, Supargiyono, Supargiyono, Sutanto, Inge, Syafruddin, Din, Talukdar, Arunansu, Tarning, Joel, Taylor, Walter R, Ter Kuile, Feiko, Thapa, Suman, Theodora, Minerva, Thi, Thuan Nguyen, Thriemer, Kamala, van den Boogaard, Christel, Waramin, Edward, Waramori, Govert, Wongsrichanalai, Chansuda, Woyessa, Adugna, Xa, Nguyen Xuan, Yeom, Joon Sup   +97 more
core   +3 more sources

Synthesis and Chemical Characterization of Chloroquine, Hydroxychloroquine, Zinc, and Cinnamic Acid Organocomplexes: Potential Drug Candidates for SARS‐CoV‐2 Treatment and Microbial Control

ChemistrySelect, Volume 10, Issue 27, July 18, 2025.
Zn‐quinolines were synthesized with high yields of 78% and 85%. The study focuses on drug repositioning to improve properties and reduce toxicity for COVID‐19 treatment. New Zn‐based compounds demonstrated antiviral and antimicrobial activities with low toxicity.
Carla Peron, Paulo Roberto dos Santos, João Pedro de Oliveira Mezzomo, Fernando Joel Scariot, Ariel Maia, Laura Calle Gonzalez, Deise do Nascimento de Freitas, Ana Paula Longaray Delamare, Pablo Machado, Ana Paula Duarte de Souza, Sidnei Moura   +10 more
wiley   +1 more source

Interactions between tafenoquine and artemisinin-combination therapy partner drug in asexual and sexual stage Plasmodium falciparum

International Journal for Parasitology: Drugs and Drug Resistance, 2017
The 8-aminoquinoline tafenoquine (TFQ), a primaquine derivative, is currently in late-stage clinical development for the radical cure of P. vivax. Here drug interactions between TFQ and chloroquine and six artemisinin-combination therapy (ACT) partner ...
Karen Kemirembe, Mynthia Cabrera, Liwang Cui   +2 more
doaj   +1 more source

Integrated Phenotypic and Genotypic Approaches for Accurate Diagnosis of G6PD Deficiency: Implications for Drug Safety in Thailand

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency holds critical health concerns, particularly due to its association with drug‐induced hemolysis triggered by medications such as antimalarials. This condition poses significant risks in malaria‐endemic regions where the prevalence and genetic diversity of G6PD deficiency further complicate ...
Natnicha Pengsuk, Kamonwan Chamchoy, Chatnapa Duangdee, Jantawan Satayarak, Naowarat Saralamba, Wang Nguitragool, Usa Boonyuen   +6 more
wiley   +1 more source

Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial [PDF]

, 2016
Background: A single low dose (0.25 mg/kg) of primaquine is recommended as a gametocytocide in combination with artemisinin-based combination therapies for Plasmodium falciparum but its effect on post-treatment gametocyte circulation and infectiousness ...
A Ouedraogo, AC Eziefula, Alfred B. Tiono, Alice C. Eziefula, Alphonse Ouédraogo, AM Dondorp, Amidou Diarra, Bronner P. Gonçalves, C Harris, Chris Drakeley, CJ Sutherland, Débé Siaka, EA Ashley, EA Ashley, Edith C. Bougouma, G Targett, HC Slater, Helmi Pett, I Chen, Issa Nebie, J Gerardin, JM Bolscher, John Bradley, JT Bousema, Kjerstin Lanke, MJ Delves, NJ White, NJ White, P Sawa, P Schneider, P Schneider, R Wampfler, RE Paul, SA Shekalaghe, SH Adjalley, Sodiomon B. Sirima, T Bousema, T Bousema, T Bousema, Teun Bousema, TS Churcher, V Robert, W Stone, Wamdaogo M. Guelbéogo   +43 more
core   +7 more sources