Results 71 to 80 of about 2,943 (200)

Tafenoquine for the treatment of Plasmodium vivax malaria

Expert Opinion on Pharmacotherapy, 2022
Plasmodium vivax malaria causes significant disease burden worldwide, especially in Latin America, Southeast Asia, and Oceania. P. vivax is characterized by the production of liver hypnozoites that cause clinical relapses upon periodic activation. Primaquine, an 8-aminoquinoline drug, has been the standard of care for decades to treat liver-stage P ...
Alejandro, Llanos-Cuentas, Paulo, Manrrique, Angel, Rosas-Aguirre, Sonia, Herrera, Michelle S, Hsiang   +4 more
openaire   +2 more sources

Clinical complications of G6PD deficiency in Latin American and Caribbean populations : systematic review and implications for malaria elimination programmes [PDF]

, 2014
Background: Although G6PDd individuals are generally asymptomatic throughout their life, the clinical burden of this genetic condition includes a range of haematological conditions, including acute haemolytic anaemia (AHA), neonatal jaundice (NNJ) and ...
Bassat, Quique, Brito, Marcelo, Franca, Gabriel Peixoto, Lacerda, Marcus Vinícius Guimarães de, Melo, Gisely Cardoso de, Monteiro, Wuelton Marcelo, Oliveira, Maria Regina Fernandes de, Peixoto, Henry Maia, Queiroz, Amanda de Lourdes Maciel, Romero, Gustavo Adolfo Sierra   +9 more
core   +2 more sources

Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants. [PDF]

, 2015
BACKGROUND: Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children. Few studies have explored the effects of G6PD status on hemolysis in children treated with Intermittent ...
Alifrangis, Michael, Baraka, Vito, Carneiro, Ilona, Chandramohan, Daniel, Gesase, Samwel, Gosling, Roland, Hashim, Ramadhan, Ishengoma, Deus, Mosha, Jacklin, Poirot, Eugenie, Vittinghoff, Eric   +10 more
core   +3 more sources

A first example of cobalt-catalyzed remote C-H functionalization of 8-aminoquinolines operating through a single electron transfer mechanism [PDF]

, 2016
The development of new C[BOND]H functionalization protocols based on inexpensive cobalt catalysts is currently attracting significant interest. Functionalized 8-aminoquinoline compounds are high-potential building blocks in organic chemistry and ...
Ackermann, Cong, Corbet, Donaldson, Dong, Fors, Galliker, Gandy, Goldstein, Grossi, Guo, Guo, He, Hong, Hu, Iwai, Katayev, Kilpatrick, Kochi, Koley, Liang, Liu, Liu, Maity, Moselage, Nakata, Olah, Ono, Planas, Qiao, Recht, Sahoo, Saito, Seuss, Taniguchi, Wang, Wei, Wei, Williams, Xia, Xu, Yan, Yan, Yoon, Zhang, Zhang, Zhang, Zhao, Zhou, Zhu   +49 more
core   +1 more source

Pharmacogenomic Calling From Whole‐Exome Sequencing in the Taiwanese Population—A Real‐World Experience

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
This study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Hsu‐Heng Lin, Meng‐Ju Melody Tsai, Hui‐An Chen, Rai‐Hseng Hsu, Yun‐Syuan Lin, Yi‐Lin Lin, Ching Hsu, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Ni‐Chung Lee   +9 more
wiley   +1 more source

Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines

Malaria Journal, 2018
Background Tafenoquine was recently approved for Plasmodium vivax radical cure (KRINTAFEL™) and malaria prevention (ARAKODA™). Methods A review of the non-clinical and clinical literature was conducted to assess whether tafenoquine (and primaquine ...
Jonathan Berman, Tracey Brown, Geoffrey Dow, Stephen Toovey   +3 more
doaj   +1 more source

When Fever Turns Hemorrhagic in the Maldives: A Case Report of Dengue in a G6PD‐Deficient Young Adult With Hemolysis and Rhabdomyolysis

Case Reports in Infectious Diseases, Volume 2026, Issue 1, 2026.
Background Dengue is endemic in the Maldives and remains a major public health concern in this small island nation of approximately half a million people. Genetic red blood cell disorders, particularly thalassemia, are common; however, the prevalence of other inherited disorders, such as glucose‐6‐phosphate dehydrogenase (G6PD) deficiency, remains ...
Rajib Dey, Gunjan Khadka, Thuhufa Ali, Su Su Htun, Ahmed Miqdhaadh, Nestor Arce Jr., Wasin Matsee, Prakaykaew Charunwatthana, Hisham Imad, Priya Gusain   +9 more
wiley   +1 more source

Prevalence of glucose 6-phosphate dehydrogenase deficiency in highly malaria-endemic municipalities in the Brazilian Amazon: A region-wide screening study

The Lancet Regional Health. Americas, 2022
Summary: Background: Difficulties associated with the assessment of glucose-6-phosphate dehydrogenase deficiency (G6PDd), particularly in remote areas, hinders the safe use of 8-aminoquinolines such as primaquine (PQ) and tafenoquine against Plasmodium ...
Joabi Rocha Nascimento, Jose Diego Brito-Sousa, Anne Cristine Gomes Almeida, Marly M Melo, Monica Regina Farias Costa, Laila Rowena Albuquerque Barbosa, Reinaldo Nery Ramos, Alexandre Vilhena Silva-Neto, Patricia Carvalho da Silva Balieiro, Erick Frota Gomes Figueiredo, Emanuelle Lira Silva, Djane Clarys Baia-da-Silva, Quique Bassat, Gustavo Romero, Gisely Cardoso Melo, Vanderson Souza Sampaio, Marcus Lacerda, Wuelton Monteiro   +17 more
doaj   +1 more source

Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT The 8-aminoquinoline tafenoquine showed significant in vitro activity against Leishmania species, including L. donovani amastigotes in macrophages, with 50% inhibitory concentrations (IC 50 s) between 0.1 and 4.0 μM for both ...
Vanessa, Yardley, Francisco, Gamarro, Simon L, Croft   +2 more
openaire   +3 more sources

Reimagining Social Value to Consider the Environment: How Should We Judge the Magnitude of Benefits in Health Research?

Bioethics, Volume 39, Issue 9, Page 821-833, November 2025.
ABSTRACT Growing recognition of intersections between our health and the environment, healthcare systems and the environment, and health research and the environment has led bioethics scholars to advocate that the field readopt a broader perspective that considers nature.
Bridget Pratt, Rieke van der Graaf
wiley   +1 more source