Results 51 to 60 of about 2,943 (200)
Effects of Antimalarial Tafenoquine on Blood Platelet Activity and Survival
Cellular Physiology and Biochemistry, 2017 Background/Aims: The 8-aminoquinoline tafenoquine has been shown to be effective against Plasmodia, Leishmania and Trypanosoma. The substance is at least in part effective by triggering apoptosis of the parasites.
Hang Cao +5 more
doaj +1 more source
Approval of Tafenoquine for Malaria Chemoprophylaxis [PDF]
The American Journal of Tropical Medicine and Hygiene, 2019 Malaria chemoprophylaxis has become increasingly prominent now that it is used for vulnerable populations in endemic regions in addition to nonimmune travelers to those regions. The objective would be a drug with > 95% efficacy and that is easily tolerated, including in children and pregnant women. For individuals who prefer weekly rather than daily
openaire +2 more sources
Review of mass drug administration for malaria and its operational challenges. [PDF]
, 2015 Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance.
Chen, Ingrid +12 more
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International Journal of Pharmaceutical Sciences and Drug Research, 2022 The most prevalent parasite disease in humans is malaria. According to estimates, 3 billion individuals worldwide are at danger of developing this illness. For the quantitative detection of tafenoquine, a brand-new, quick, and accurate stability-indicating high performance liquid chromatographic method was created and validated.
Mayur Sanjay Tekade +3 more
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Discovery of potent, novel, non-toxic anti-malarial compounds via quantum modelling, virtual screening and in vitro experimental validation [PDF]
, 2011 Background Developing resistance towards existing anti-malarial therapies emphasize the urgent need for new therapeutic options. Additionally, many malaria drugs in use today have high toxicity and low therapeutic indices.
David J Sullivan +2 more
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Adverse effects of the antimalaria drug, mefloquine: due to primary liver damage with secondary thyroid involvement? [PDF]
, 2002 Background Mefloquine is a clinically important antimalaria drug, which is often not well tolerated. We critically reviewed 516 published case reports of mefloquine adverse effects, to clarify the phenomenology of the harms associated with mefloquine ...
Ashley M Croft +78 more
core +2 more sources
Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria? [PDF]
, 2016 Progress made in malaria control during the past decade has prompted increasing global dialogue on malaria elimination and eradication. The product development pipeline for malaria has never been stronger, with promising new tools to detect, treat, and ...
Achee, Nicole +6 more
core +3 more sources
Anti‐malarial drug effects on parasite dynamics in vivax malaria
Malaria Journal, 2021 Relapses of Plasmodium vivax malaria are prevented by 8-aminoquinolines. If hypnozoites survive, then the subsequent blood stage infections in early relapses (
Nicholas J. White
doaj +1 more source
Global Emergency Medicine: A Review of the Literature From 2013 [PDF]
, 2014 Objectives The Global Emergency Medicine Literature Review ( GEMLR ) conducts an annual search of peer‐reviewed and grey literature relevant to global emergency medicine ( EM ) to identify, review, and disseminate the most important new research in this
Ackaah +34 more
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