Survey and Analysis of Chemoprophylaxis Policies for Domestic Travel in Malaria-Endemic Countries
Tropical Medicine and Infectious Disease, 2022 The prevention of malaria in travelers with the use of antimalarials often occurs in connection with international travel to areas of significant risk of infection.
John Kevin Baird +2 more
doaj +1 more source
Tafenoquine — A Radical Improvement? [PDF]
New England Journal of Medicine, 2019 Plasmodium vivax is a major cause of malaria in the Americas, the Horn of Africa, and Asia. P. vivax malaria has a propensity to recur (relapse), often multiple times, after resolution of the initi...
openaire +3 more sources
Heterogeneity of G6PD deficiency prevalence in Mozambique: a school-based cross-sectional survey in three different regions [PDF]
, 2017 Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked hereditary enzymatic abnormality that affects more than 400 million people worldwide.
Aide, Pedro Carlos Paulino +11 more
core +4 more sources
Simple In Vitro Assay for Determining the Sensitivity of Plasmodium vivax Isolates from Fresh Human Blood to Antimalarials in Areas where P. vivax Is Endemic [PDF]
, 2003 The aim of this study was to develop a simple, field-practical, and effective in vitro method for determining the sensitivity of fresh erythrocytic Plasmodium vivax isolates to a range of antimalarials.
Russell, BM +5 more
core +1 more source
Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria. [PDF]
PLoS Neglected Tropical Diseases, 2018 The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with
James Watson +5 more
doaj +1 more source
Differential activity of methylene blue against erythrocytic and hepatic stages of Plasmodium [PDF]
, 2018 Background: In the context of malaria elimination/eradication, drugs that are effective against the different developmental stages of the parasite are highly desirable.
Borrmann, Steffen +12 more
core +2 more sources
Tafenoquine for the prevention of Plasmodium vivax malaria relapse [PDF]
The Lancet Microbe, 2021 La tafenoquina (Krintafel) es el primer fármaco nuevo aprobado para el tratamiento de la malaria por Plasmodium vivax recidivante en 70 años. La tafenoquina se diseñó para ser una versión metabólicamente estable y, por lo tanto, se eliminó lentamente de la 8-aminoquinolina, primaquina, proporcionando prevención de recaídas con una dosis única en ...
James A Watson +2 more
doaj +3 more sources
The role of anti-malarial drugs in eliminating malaria [PDF]
, 2008 Effective anti-malarial drug treatment reduces malaria transmission. This alone can reduce the incidence and prevalence of malaria, although the effects are greater in areas of low transmission where a greater proportion of the infectious reservoir is ...
A Bhattarai +60 more
core +3 more sources
Antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes [PDF]
, 2016 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and ...
Kunwittaya, Sarun +6 more
core +1 more source
A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials [PDF]
, 2016 Objectives: A future treatment for uncomplicated malaria will contain at least one component that exerts a rapid rate of kill (RoK). We describe here the validation and application of a simple, robust and rapid bioluminescence-based assay for the ...
Biagini, Giancarlo +3 more
core +4 more sources