Results 31 to 40 of about 2,943 (200)
Population pharmacokinetics of tafenoquine during malaria prophylaxis in healthy subjects [PDF]
, 2007 The population pharmacokinetics of tafenoquine were studied in Australian soldiers taking tafenoquine for malarial prophylaxis. The subjects (476 males and 14 females) received a loading dose of 200 mg tafenoquine base daily for 3 days, followed by a ...
Charles, B. G. +5 more
core +1 more source
Development and application of a PBPK modeling strategy to support antimalarial drug development
CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 9, Page 1335-1346, September 2023., 2023 Abstract As part of a collaboration between Medicines for Malaria Venture (MMV), Certara UK and Monash University, physiologically‐based pharmacokinetic (PBPK) models were developed for 20 antimalarials, using data obtained from standardized in vitro assays and clinical studies within the literature.
Nada Abla +17 more
wiley +1 more source
British Journal of Haematology, Volume 202, Issue 5, Page 1024-1032, September 2023., 2023 Genetic variants of G6PD causing G6PD deficiency make red cells vulnerable to oxidative damage. From a literature review we have compiled data on 2291 G6PD deficient male subjects and determined the residual G6PD activity associated with 17 common variants of G6PD: the values range from 2 to 33% of normal. With respect to the WHO classification of G6PD
Caterina Nannelli +4 more
wiley +1 more source
Pathogens, 2023 Plasmodium vivax cases represent more than 50% of a diminishing malaria case load in Vietnam. Safe and effective radical cure strategies could support malaria elimination by 2030.
Emily Gerth-Guyette +10 more
doaj +1 more source
KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. [PDF]
, 2014 Preventing relapses of Plasmodium vivax malaria through a radical cure depends on use of the 8-aminoquinoline primaquine, which is associated with safety and compliance issues.
Borboa, Rachel +25 more
core +1 more source
Blood microsampling technologies: Innovations and applications in 2022
Analytical Science Advances, Volume 4, Issue 5-6, Page 154-180, July 2023., 2023 Abstract With the development of highly sensitive bioanalytical techniques, the volume of samples necessary for accurate analysis has reduced. Microsampling, the process of obtaining small amounts of blood, has thus gained popularity as it offers minimal‐invasiveness, reduced logistical costs and biohazard risks while simultaneously showing increased ...
Manchu Umarani Thangavelu +4 more
wiley +1 more source
Parasites & Vectors, 2020 Background Babesiosis represents a veterinary and medical threat, with a need for novel drugs. Artemisinin-based combination therapies (ACT) have been successfully implemented for malaria, a human disease caused by related parasites, Plasmodium spp.
Leonardo J. M. Carvalho +4 more
doaj +1 more source
Tackling resistance: Emerging antimalarials and new parasite targets in the era of elimination [version 1; referees: 2 approved] [PDF]
, 2018 Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites.
Matthews, Emily S, Odom John, Audrey R
core +2 more sources
British Journal of Clinical Pharmacology, Volume 89, Issue 3, Page 1187-1197, March 2023., 2023 Aim Microsampling has the advantage of smaller blood sampling volume and suitability in vulnerable populations compared to venous sampling in clinical pharmacokinetics studies. Current regulatory guidance requires correlative studies to enable microsampling as a technique.
Sagar S. Bachhav +8 more
wiley +1 more source
Malaria Journal, 2011 Background Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance times, and toxicity in glucose-6-
Kenworthy David +12 more
doaj +1 more source