Results 101 to 110 of about 373,907 (280)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Of course we share! Testing Assumptions about Social Tagging Systems

open access: yes, 2014
Social tagging systems have established themselves as an important part in today's web and have attracted the interest from our research community in a variety of investigations.
Doerfel, Stephan   +5 more
core  

Movements of Channel Catfish and Flathead Catfish in Beaver Reservoir, Northwest Arkansas [PDF]

open access: yes, 1978
A total of 497 channel catfish, Ictalurus punctatus, and flathead catfish, Pylodictis olivaris. were tagged in Beaver Reservoir during two November-April tagging periods (1967-68 and 1968-69); total recaptures were 9.5 and 11.7% respectively. The longest
Duncan, Thomas O., Myers, Milton R., Jr.
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Conservation of Native Fishes of the San Francisco Estuary: Considerations for Artificial Propagation of Chinook Salmon, Delta Smelt, and Green Sturgeon

open access: yesSan Francisco Estuary and Watershed Science, 2011
Many native fishes in the San Francisco Estuary and its watersheds have reached all-time low abundances. Some of these declining species (e.g., Chinook salmon Oncorhynchus tschawytscha) have been under artificial propagation for decades. For others (e.g.,
Joshua A. Israel   +3 more
doaj  

b-Tagging Algorithms and their Performance at ATLAS [PDF]

open access: yes, 2008
The ability to identify jets containing B hadrons is important for the high-pT physics program of a general-purpose experiment such as ATLAS. b-tagging is in particular useful for selecting very pure top quark samples, for studying standard model or ...
Lehmacher, Marc
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Anidación de la tortuga Dermochelys coriacea (Testudines: Dermochelyidae) en playa Gandoca, Costa Rica (1990 a 1997)

open access: yesRevista de Biología Tropical, 1999
La anidación de la tortuga baula fue estudiada en playa Gandoca, una importante playa de anidación de tortugas marinas localizada al sureste de la costa Caribeña de Costa Rica, dentro de los límites del Refugio Nacional de Vida Silvestre Gandoca ...
Didiher Chacón Chaverri
doaj  

Using Rhodamine to Tag Mites for Studies of Pre‐ and Post‐Copulatory Sexual Selection

open access: yesEcology and Evolution
Our understanding of sexual selection is advancing with new technologies that tag individuals or their sperm, revealing how females use post‐copulatory processes to discriminate between competing mates.
Anastasia J. Shavrova   +2 more
doaj   +1 more source

A pilot experiment of tagging the deep shrimp Aristeus antennatus (Risso, 1816)

open access: yesScientia Marina, 2000
A tagging experiment of the blue and red shrimp, Aristeus antennatus was carried out in the Ionian Sea, off Roccella Jonica (RC). The experiment involved 45 shrimps, caught by trawling at night at about 100-150 m in depth.
M. Relini   +5 more
doaj   +1 more source

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