Results 91 to 100 of about 257,409 (278)

The monoamine transporter inhibitor duloxetine causes a buprenorphine-selective enhancement of tail flick anti-nociception.

, 2019
Male CD-1 mice were tested for tail flick anti-nociception baselines with 52°C water (10 second cutoff). The mice were then injected with duloxetine (20 mg/kg) or vehicle (1% Tween80 in saline) by the intraperitoneal route for 10 minutes, followed by ...
Daniel Womer (6807767), John M. Streicher (503153), Keith M. Olson (1484329), David I. Duron (6807764), Ryan Fell (6807770)   +4 more
core   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Evaluation of Antinociceptive Efficacy of pre Versus post-Incisional Morphine, Tramadol or Meloxicam in Rats [PDF]

Iranian Journal of Veterinary Surgery, 2015
Objective- To evaluate antinociceptive efficacy of pre- versus post-incisional morphine, tramadol and meloxicam using tail-flick test in an incisional model of pain in rats. Design- Prospective, randomized experimental study. Animals- Eighty, adult, male
Nasser Vesal, Mehrzad Foroud
doaj  

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Effects of Alcoholic Extract of Portulaca Oleracea on Modulation of Neuropathic and Acute Pain in Rats

Iranian South Medical Journal, 2019
Background: Portulaca Oleracea is a medicinal plant with many effects including analgesic and anti-inflammatory properties. This study aimed to investigate the effect of alcoholic extract of Portulaca Olerecea on CCI model of neuropathic pain (Bennet ...
Mehdi Sadeghi, Afsaneh Vahedi Moghadam, Ali Movahed   +2 more
doaj  

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Effects of BHE and morphine stimulated by IR in the tail–flick test.

, 2015
The data represent the mean ± SEM (n = 10).ap < 0.05bp < 0.01cp < 0.001 (ANOVA, followed by the Dunnett's test).Effects of BHE and morphine stimulated by IR in the tail–flick test.
Jinlong Xu (689841), Lei Wei (18880), Qizhi Zhao (689842), Rui Xu (158313), Yimin Zhao (689844), Yu Yang (83671), Nengjiang Yu (689843)   +6 more
core   +1 more source

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

Uji Efek Analgesik Sentral Asetosal Pada Mencit Betina Menggunakan Alat Tail Flick Modifikasi Versi 4

, 2004
Telah dilakukan penelitian mengenai uji efek analgesik sentral asetosal pada hewan uji mencit betina (Mus musculus) dengan menggunakan alat Tail Flick modifikasi versi 4 dengan menggunakan metode termal.
Kartika, Fonny
core   +2 more sources

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source