Results 101 to 110 of about 257,409 (278)

Study the Antinociceptive Effect of Intracerebroventricular Injection of Aqueous Extract of Origanum Vulgare Leaves in Rat: Possible Involvement of Opioid System [PDF]

Iranian Journal of Basic Medical Sciences, 2013
Objective(s): The aim of study was to investigate the antinociceptive effect of intracerebroventricular (ICV) microinjection of Origanum vulgare (ORG) extract and possible involvement of opioid receptors.
Yasaman Pahlavan, Gholamreza Sepehri, Vahid Sheibani, Mohammadreza Afarinesh khaki, Morteza Gojazadeh, Bahare Pahlavan, Fereshteh Pahlavan   +6 more
doaj  

Mechanistic assessment of the analgesic, anti-inflammatory and antipyretic actions of Dalbergia saxatilis in animal models

Pharmaceutical Biology, 2017
Context: Aqueous root extract of Dalbergia saxatilis, Hook, f., (Leguminosae) (DS) is reported useful for toothache, pains, and fever, but not scientifically proven.
Omoniyi K. Yemitan, Olufunmilayo O. Adeyemi   +1 more
doaj   +1 more source

Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced Gastrotoxicity. [PDF]

Int J Mol Sci, 2020
Szandruk-Bender M, Wiatrak B, Szczukowski Ł, Świątek P, Rutkowska M, Dzimira S, Merwid-Ląd A, Danielewski M, Szeląg A.   +8 more
europepmc   +1 more source

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

Advanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka, Marian Bienstein, Jonas Berger, Ulrich Schwaneberg   +3 more
wiley   +1 more source

ANALGESIC AND ANTIINFLAMMATORY EFFECTS OF TOTAL EXTRACT, FLAVONOID FRACTION AND VOLATILE OIL OF SALVIA HYDRANGEA

Journal of Research in Medical Sciences, 2000
Background. Gol-e-arvaneh with the scientific name of salvia hydrangea (Labiatea) belongs to Salvia genus. In traditional medicine it has been used as analgesic, relieving headache, cold remedy, antipyretic and diuretic.
V.A HAJ HASHEMI, A GHANADI, D MOSAVI
doaj  

Synthesis and analgesic activities of some new 5-chloro-2(3H)-benzoxazolone derivatives

The EuroBiotech Journal, 2017
Affordable and practical synthesis methods in drug development have always been very attractive. Herein, microwave assisted synthesis was utilized to prepare piperazine substituted 5-chloro-2(3H)-benzoxazolone derivatives in 5 minutes.
Mulazim Yusuf, Berber Cevdet, Erdogan Hakkı, Ozkan Melike Hacer, Kesanli Banu   +4 more
doaj   +1 more source

Intrathecal endomorphin-1 produces antinociceptive activities modulated by alpha 2-adrenoceptors in the rat tail flick, tail pressure and formalin tests

, 2000
It is known that spinal morphine produces antinociception that is modulated by alpha 2-adrenoceptors. Endomorphin-1, a newly-isolated endogenous opioid ligand, shows the greatest selectivity and affinity for the mu-opiate receptor of any endogenous ...
Hao, Shuanglin, Iwasaki, Hiroshi, Takahata, Osamu, Shuanglin Hao, Osamu Takahata, Hiroshi Iwasaki   +5 more
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Diclofenac pretreatment alters morphine antinociception in warm-water (52°C) tail flick assay.

, 2014
Effect of diclofenac (Diclo, 30 mg/kg) administration on morphine (10 mg/kg) antinociception was assessed by warm-water tail flick. A) Time-effect curves showing an increase in tail flick latency that peaks 60 min post morphine dosing and is declining by
Lucy Sanchez-Covarrubias (521451), Lauren M. Slosky (521452), Brandon J. Thompson (521453), Thomas P. Davis (521458), Kristin M. DeMarco (521456), Patrick T. Ronaldson (521457), Yifeng Zhang (521454), Mei-Li Laracuente (521455)   +7 more
core   +1 more source

Herbivory‐Induced Stomatal Opening Triggers the Dispersal of an Invasive Insect Herbivore

Advanced Science, EarlyView.
The invasive leafminer Phthorimaea absoluta uniquely manipulates plant defenses by inducing stomatal opening in tomato. This response, mediated by the stomatal regulator IQM1, enhances the release of the repellent volatile benzaldehyde. This volatile triggers the dispersal of adult moths, facilitates colonization of new hosts, and leads to rapid ...
Limin Chen, Xiaowei Li, Yaru Wang, Farman Ullah, Shuxing Zhou, Lemeng Dong, Weizhong He, Harro J. Bouwmeester, Youming Hou, Ian T. Baldwin, Yaobin Lu   +10 more
wiley   +1 more source