Results 221 to 230 of about 257,409 (278)

Pharmacokinetics and pharmacodynamics of cannabigerol (CBG) in the C57BL/6Crl mouse. [PDF]

Front Pharmacol
Zagzoog A, Halter K, Ha N, Jones AM, Andres R, Kim A, Michel D, Alcorn J, Laprairie RB.   +8 more
europepmc   +1 more source

Molecular Docking and Experimental Evaluation of Trolox and Neocuproine in Targeting Neuroinflammation in Neuropathic Pain Model. [PDF]

J Biochem Mol Toxicol
Yaman S, Akcay G, Yesilyurt F, Yildirim M.   +3 more
europepmc   +1 more source

OnabotulinumtoxinA inhibits dysregulation of descending pain modulation following mild traumatic brain injury in mice. [PDF]

J Headache Pain
Vizin RCL, Kopruszinski CM, Oyarzo JN, Dodick DW, Broide RS, Brideau-Andersen AD, Brin MF, Anderson T, Navratilova E, Porreca F.   +9 more
europepmc   +1 more source

Development of Bioisosteres of Iboga Alkaloids: A Step-Economical Synthesis to Enhance the Antinociceptive and Anxiolytic Activity with Neuroprotective Effects. [PDF]

ACS Pharmacol Transl Sci
Gupta A, Bhattacharya T, Pratihar S, Parvage S, Sharma SN, Sarkar A, De A, Karmakar S, Dey S, Sinha S.   +9 more
europepmc   +1 more source

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Response Latencies in the Tail-Flick Test Depend on Tail Skin Temperature

Neuroscience Letters, 1988
Tail skin temperatures and tail-flick latencies were simultaneously recorded in male Sprague-Dawley rats exposed to various ambient temperatures (22-30 degrees C). There was a positive correlation between tail skin temperature and ambient temperature and a negative correlation between tail-flick latency and ambient temperature.
Kjell Jorgen Hole, Odd-Geir Berge, O G Berge   +2 more
exaly   +3 more sources

An Improved Method for Tail-Flick Testing With Adjustment for Tail-Skin Temperature

Journal of Neuroscience Methods, 1989
The tail-skin temperature is an important factor in determining tail-flick latency to noxious radiant heat in rats and mice. A simple, non-invasive method for recording the tail-skin temperature during conventional tail-flick testing is described. The method is conveniently performed during conventional tail-flick testing.
Anders Lund, Kjell Jorgen Hole, Odd-Geir Berge   +2 more
exaly   +3 more sources

A Quantitative Study on the Tail Flick Test in the Rat

Physiology and Behavior, 1987
Tail flick latency and response temperature were measured in awake rats. Both of these parameters varied with the change in rate of increase of radiant heat stimulus and the area of skin irradiated. The caloric factor applied to the tail before the response occurred was calculated approximately from the time-temperature curves monitored over the tail ...
Masaya Funakoshi, Kenji Kawakita, K Kawakita   +2 more
exaly   +3 more sources

The Tail-Flick Latency Is Influenced by Skin Temperature

APS Journal, 1993
The tail-flick test is an extensively used test for nociception in rats and mice. Noxious heat is applied to the tail, and the latency for a withdrawal response is measured. The pretest temperature of the tail skin is an important factor influencing the tail-flick latency, which is inversely correlated with the temperature.
Kjell Jorgen Hole, Arne Tjølsen
exaly   +2 more sources

Dopaminergic Effects on Tail-Flick Response in Spinal Rats

European Journal of Pharmacology, 1982
R-Apomorphine (0.02-1.75 mumol/kg), administered by intrathecal infusion to spinalized rats, caused a dose-dependent increase in tail-flick latency. The effect of R-apomorphine was counteracted significantly by the dopaminergic receptors antagonists cis-flupenthixol (0.20-3.94 mumol/kg) and (+)-butaclamol (0.78 mumol/kg), but not by their enantiomers ...
Donald F Smith, D F Smith
exaly   +4 more sources

Evaluation of Narcotic Analgetic Activity Using a Cat Tail-Flick Procedure

Journal of Pharmacological Methods, 1979
A classical narcotic analgetic testing procedure, the thermal-induced rat tail-flick, has been adapted for utilization in cats. The feline tail-flick method is simple to perform and is a sensitive, specific, and reproducible test for evaluation of ...
Frederick J Goldstein
exaly   +1 more source