Results 241 to 250 of about 7,425,562 (280)
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Effects of B-HT 920 in the Tail-Suspension Test
Pharmacological Research, 1991The effect of B-HT 920 on mice subjected to the tail-suspension test (TST), a behavioural tool for gauging depression, was studied. During the test, all the animals had bouts of agitation interspersed with periods of immobility but B-HT 920-treated animals exhibited a differentiated behavioural pattern according to the dose employed: at doses selective
Francesca Ferrari
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The tail suspension test: Ethical considerations
Psychopharmacology, 1986The above analysis of haemodynamic, behavioral, physiological and pharmacological factors concord in suggesting that the Tail Suspension Test is considerably less stressful to experimental animals than the traditional “behavioral despair” test. It should always be borne in mind, however, that any attempt to model depression in animals by definition ...
B, Thierry +3 more
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Strain Differences in Response to Drugs in the Tail Suspension Test for Antidepressant Activity
Psychopharmacology, 1987The effects of several types of antidepressants in a recently developed "behavioural despair" model, the tail-suspension test, are described. Drug effects on the automatically recorded duration of immobility and power of movements were measured in three strains of mice. Only in one strain (NMRI) did almost all antidepressants tested showed the expected
B Olivier
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Interaction of zinc with antidepressants in the tail suspension test
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008The antidepressant-like effect of zinc has been shown in several animal models of depression. In this study, zinc chloride (ZnCl2) was given alone or in combination with different classes of antidepressants by oral route (p.o.) to mice and the behavioral response in the tail suspension test (TST), a predictive test of antidepressant action, was ...
Mauricio P, Cunha +4 more
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European Journal of Pharmacology, 2010 Melatonin was previously shown to produce an antidepressant-like effect in the tail suspension test. In this work the mechanisms underlying its antidepressant-like effect were further studied by investigating the involvement of the dopaminergic system in its antidepressant-like effect in the tail suspension test.
Ana Lúcia S Rodrigues +2 more
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Electrotherapy in mice: dopaminergic and noradrenergic effects in the Tail Suspension Test
Fundamental & Clinical Pharmacology, 1990Summary— The Tail Suspension Test (TST) is a psychotropic screening test which is used principally to detect antidepressant activity. Electrotherapy (ECT) is used to treat depressions which are resistant to the usual antidepressant drugs and has proved to have a profile in the TST approaching that of antidepressants after treating mice at the rate of 2
J F, Teste, I, Martin, P, Rinjard
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The tail suspension test: A new method for screening antidepressants in mice
Psychopharmacology, 1985A novel test procedure for antidepressants was designed in which a mouse is suspended by the tail from a lever, the movements of the animal being recorded. The total duration of the test (6 min) can be divided into periods of agitation and immobility. Several psychotropic drugs were studied: amphetamine, amitriptyline, atropine, desipramine, mianserin,
L, Steru +3 more
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Genetic differences in a tail suspension test for evaluating antidepressant activity
Psychopharmacology, 1989Tail suspension-induced immobility in rodents is specifically antagonized by antidepressants, and has been proposed as an animal model of depression. Marked differences in tail suspension-induced immobility were observed among nine inbred mouse strains, ranging from 1 +/- 0.3 to 96 +/- 8-s in a 300-s test period.
R, Trullas, B, Jackson, P, Skolnick
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Limitations on the use of the C57BL/6 mouse in the tail suspension test
Psychopharmacology, 2001The C57BL/6 is one of the most widely used mouse strains in behavioral, pharmacological, and genetic research but little is known about their response on tests for antidepressant drugs.The behavior of C57BL/6 mice, and mice from other strains, was examined in the tail suspension test (TST), a common behavioral test used for the screening of ...
A J, Mayorga, I, Lucki
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Assessment Time Affects the Outcome of the Tail Suspension Test
Biological Rhythm Research, 2011The mouse tail suspension test (TST) is a method to screen antidepressants. Antidepressants reduce the amount of time spent immobile during the TST. A confounder in the TST is tail-climbing. The vast majority of studies using the TST perform the test during the mouse's sleep cycle.
Nicole Mohrbacher +2 more
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