Results 251 to 260 of about 7,425,562 (280)
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Life Sciences, 2007
This study investigated the effect of berberine (BER) in the mouse forced swim test (FST) and in the tail suspension test (TST), two models predictive of antidepressant activity. We also investigated the antidepressant-like mechanism of BER by the combination of the desipramine [DES, an inhibitor of reuptake of noradrenaline (NA) and serotonin (5-HT)],
Wen-Huang Peng, Ying-Chih Lin
exaly +3 more sources
This study investigated the effect of berberine (BER) in the mouse forced swim test (FST) and in the tail suspension test (TST), two models predictive of antidepressant activity. We also investigated the antidepressant-like mechanism of BER by the combination of the desipramine [DES, an inhibitor of reuptake of noradrenaline (NA) and serotonin (5-HT)],
Wen-Huang Peng, Ying-Chih Lin
exaly +3 more sources
Antidepressant-like effects in various mice strains in the tail suspension test
Behavioural Brain Research, 2003Several studies have reported rodent strain differences in the response to antidepressants in animal models of depression. The aim of the present study was to investigate the potential contribution of genetic factors to antidepressant response in an animal model of depression: the tail suspension test (TST).
Nadège, Ripoll +4 more
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Fundamental & Clinical Pharmacology, 2003
AbstractMicrodialysis, binding and behavioural studies have shown that the dopaminergic system plays a role in antidepressant treatment. It has been suggested that stress may provoke a modification in dopamine (DA) release in different brain areas and that the forced swimming test (FST), in its own accord as a stressor, may be responsible for this ...
Caroline E, Renard +4 more
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AbstractMicrodialysis, binding and behavioural studies have shown that the dopaminergic system plays a role in antidepressant treatment. It has been suggested that stress may provoke a modification in dopamine (DA) release in different brain areas and that the forced swimming test (FST), in its own accord as a stressor, may be responsible for this ...
Caroline E, Renard +4 more
openaire +2 more sources
Adaptation of the tail suspension test to the rat.
Journal de pharmacologie, 1987In the tail suspension test (TST), the rat is suspended by the tail for 6 min during which the animal shows periods of agitation and immobility. The duration of the immobility is measured. Desipramine decreased the duration of immobility. The main advantages of this procedure are: the use of a simple, objective test situation; the concordance of the ...
R, Chermat +4 more
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Citalopram's mechanism for decreasing immobility time in the Tail Suspension Test
The FASEB Journal, 2016Different antidepressants often target common serotonergic and dopaminergic systems. However, antidepressants are not 100% effective suggesting that there are still multiple cellular mechanisms contributing to depression. Antidepressant responses by novel compounds are typically identified in preclinical models using the Tail Suspension Test (TST), a ...
Rody Kingston, Hope Pan, Ana Carneiro
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NeuroReport, 2000
L-Arginine (L-Arg), a substrate for nitric oxide synthase (NOS) at a dose of 250-500 mg/kg, i.p., significantly reduced the duration of immobility both in the forced swimming test (FST) and in the tail suspension test (TST), two models of depression in mice, without changing locomotion in an open field. Paradoxically, a similar effect was observed with
G D, da Silva +4 more
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L-Arginine (L-Arg), a substrate for nitric oxide synthase (NOS) at a dose of 250-500 mg/kg, i.p., significantly reduced the duration of immobility both in the forced swimming test (FST) and in the tail suspension test (TST), two models of depression in mice, without changing locomotion in an open field. Paradoxically, a similar effect was observed with
G D, da Silva +4 more
openaire +2 more sources
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006
Putrescine, a polyamine present at high concentrations in the mammalian brain, was suggested to play a role in the modulation of depression. Thus, this study investigated the effect of putrescine in the mouse forced swimming test (FST) and in the tail suspension test (TST), two models predictive of antidepressant activity.
Andrea D E, Zomkowski +2 more
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Putrescine, a polyamine present at high concentrations in the mammalian brain, was suggested to play a role in the modulation of depression. Thus, this study investigated the effect of putrescine in the mouse forced swimming test (FST) and in the tail suspension test (TST), two models predictive of antidepressant activity.
Andrea D E, Zomkowski +2 more
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[The tail suspension test: its theory and practical application].
Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1993The tail suspension test (TST) was originally proposed by Steru et al (1985) as a primary screening test of anti-depressant drugs. In this test, it is shown that tail suspension-induced immobility of mice is specifically antagonized by such drugs. More recently, the automated version of TST (ITEMATIC-TST) was developed by the same authors.
S, Nomura, R, Naruse, H, Okada
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The automated tail suspension test: A computerized device which differentiates psychotropic drugs
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19871. Mice when suspended by the tail will alternate between active attempts to escape and immobility. Immobility like that measured in the behavioral despair test is reduced by a wide variety of antidepressant agents. 2. The present paper describes a computerized version of this test (ITEMATIC-TST) which in addition to recording immobility measures the ...
L, Steru +7 more
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BIOCHEMICAL BACKGROUND OF THE TAIL SUSPENSION TEST.
Clinical Neuropharmacology, 1992R. Naruse +5 more
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