Results 1 to 10 of about 6,240 (95)

Regular intake of caffeinated but not decaffeinated coffee attenuates behavioral modifications in mice subject to chronic unpredictable stress [PDF]

Neurobiology of Stress
The regular intake of moderate doses of coffee is increasingly recognized as a lifestyle factor associated with a lower incidence of depressive-like conditions; however, there is still a debate on the relative effects of caffeinated and decaffeinated ...
Ângelo R. Tomé, Nuno J. Machado, Ana Paula Ardais, Ana Nunes, Henrique B. Silva, Manuella P. Kaster, Paula Agostinho, Rodrigo A. Cunha   +7 more
doaj   +2 more sources

Synthesis, Antidepressant-like and Anxiolytic-like Effects of Novel Thiadiazole Derivatives: Behavioral Assessment and Mechanistic Investigation [PDF]

Pharmaceuticals
Background/Objectives: Based on the central nervous system-related activity potential of 1,3,4-thiadiazole derivatives, novel 1,3,4-thiadiazole compounds were synthesized, and their possible antidepressant-like and anxiolytic-like effects were ...
Ümmühan Kandemir, Gizem Türkoğlu Sağlık, Derya Osmaniye, Zafer Asım Kaplancıklı, Özgür Devrim Can, Ümide Demir Özkay   +5 more
doaj   +2 more sources

Antidepressant Potential of Diphenyl Dimethyl Bicarboxylate (DDB) in a Modified Forced Swimming Test

Archives of Pharmaceutical Sciences Ain Shams University, 2021
Biphenyl Dimethyl Dicarboxylate (DDB); is an analogue of schisandrin C, a component isolated from Fructus Schisandrae Chinensis. It is now attracting growing attention for its polypharmacotherapeutic properties as an antiviral, hepatoprotective, and ...
Amal Mahfoz
doaj   +1 more source

Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives

Molecules, 2017
Within the scope of our new antidepressant drug development efforts, in this study, we synthesized eight novel benzothiazole derivatives 3a–3h. The chemical structures of the synthesized compounds were elucidated by spectroscopic methods.
Ümide Demir Özkay, Ceren Kaya, Ulviye Acar Çevik, Özgür Devrim Can   +3 more
doaj   +1 more source

Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms

Molecules, 2018
Novel benzazole derivative compounds 4a⁻4h were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds were elucidated by FT-IR,
Gamze Tokgöz, Ümide Demir Özkay, Derya Osmaniye, Nazlı Turan Yücel, Özgür Devrim Can, Zafer Asım Kaplancıklı   +5 more
doaj   +1 more source

Antidepressant-like effects of quercetin in mice: evidence for the involvement of monoaminergic mechanisms

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Recent evidence suggests that quercetin, which has the structure 3,3’,4’,5,7-pentahydroxyflavone, exhibits several central nervous system (CNS)-related activities like antinociception and cognitive enhancementas well as antidepressant-like ...
Feyza Alyu, Umide Demir Ozkay, Yusuf Ozturk   +2 more
doaj  

Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents

Molecules, 2015
In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a–s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test (MFST).
Ahmet Özdemir, Mehlika Dilek Altıntop, Zafer Asım Kaplancıklı, Özgür Devrim Can, Ümide Demir Özkay, Gülhan Turan-Zitouni   +5 more
doaj   +1 more source

Amoxicillin Induced Behavioral Neurotoxicity and Histopathological Changes in Organs of Albino Rats

Journal of College of Medical Sciences-Nepal, 2020
Background: There are various adverse drug reactions of penicillin. Neurotoxicity is attracting the attention of researchers all over the world. It also affects other organs like liver, kidney, heart and testes Methods: The study was conducted at ...
Sabita Paudel, Bijay Aryal, Sunita Ranabhat   +2 more
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Conocarpus lancifolius (Combretaceae): Pharmacological Effects, LC-ESI-MS/MS Profiling and In Silico Attributes

Metabolites, 2023
In folklore medicine, Conocarpus lancifolius is used to treat various illnesses. The main objective of this study was a comprehensive investigation of Conocarpus lancifolius leaf aqueous extract (CLAE) for its antioxidant, cardioprotective, anxiolytic ...
Muhammad Khurm, Yuting Guo, Qingqing Wu, Xinxin Zhang, Muhammad Umer Ghori, Muhammad Fawad Rasool, Imran Imran, Fatima Saqib, Muqeet Wahid, Zengjun Guo   +9 more
doaj   +1 more source

Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

The Journal of Headache and Pain, 2021
Objectives In this study, we investigated the possible analgesic effects of Botulinum toxin type A (BoNT/A) on trigeminal neuralgia (TN). A modified TN mouse model was established by chronic constriction injury of the distal infraorbital nerve (dIoN-CCI)
Wei-Jia Chen, Jing-Qi Niu, Yi-Ting Chen, Wen-Jing Deng, Ying-Ying Xu, Jing Liu, Wei-Feng Luo, Tong Liu   +7 more
doaj   +1 more source