Results 11 to 20 of about 8,885,090 (257)

Antidepressant-like effects of kynurenic acid in a modified forced swim test [PDF]

Pharmacological Reports, 2020
Abstract Background Kynurenic acid (KYNA) is an l-tryptophan metabolite with neuromodulatory activities, regulating the release of neurotransmitters such as glutamate, dopamine (DA), and acetylcholine (Ach). Dysregulation of the kynurenine pathway has been associated with neurodegenerative, neurological, and psychological disorders such as Alzheimer’s ...
Tanaka Masaru, Bohár Zsuzsanna, Martos Diána, Telegdy Gyula, Vécsei László   +4 more
openaire   +6 more sources

Neurochemical changes underlying schizophrenia-related behavior in a modified forced swim test in mice [PDF]

Pharmacology Biochemistry and Behavior, 2018
The modified forced swim test (MFST) has excellent predictive validity for investigating the antipsychotic activity of drugs, with particular emphasis on their activity toward negative symptoms of schizophrenia. However, its face and construct validity are less understood.
Monika Woźniak, Paulina Cieślik, Marcin Marciniak, Tomasz Lenda, Andrzej Pilc, Joanna M. Wieronska   +5 more
openaire   +4 more sources

Effect of Chromium Picolinate on Modified Forced Swimming Test in Diabetic Rats: Involvement of Serotonergic Pathways and Potassium Channels [PDF]

Basic & Clinical Pharmacology & Toxicology, 2006
Abstract: Depression occurs frequently in patients with diabetes mellitus. Chromium picolinate, an essential trace element is recommended for diabetes and also has been reported to benefit depression, but its mechanism is still debated. To investigate the mechanism, we studied its effects on serum insulin, serum glucose and on modified forced swimming ...
Razia, Khanam, K K, Pillai
openaire   +2 more sources

Effect of linopirdine on forced swimming test in rats

, 2019
Objective: In this study, we aimed to investigate the effect of Kv7 type voltage-gated potassium channel blocker linopirdin in Forced Swimming Test (FST) in rats.
Kahveci N., Uzunok, Barış, Büyükuysal M.Ç., Süyen G.G.   +3 more
core   +4 more sources

In-channel experiments on vertical swimming with bacteria-like robots [PDF]

, 2013
Bio-inspired micro-robots are of great importance as to implement versatile microsystems for a variety of in vivo and in vitro applications in medicine and biology.
Tabak, Ahmet Fatih, Ahmet Fatih Tabak, Yeşilyurt, Serhat, Serhat Yesilyurt   +3 more
core   +2 more sources

Modified dextromethorphan displays antidepressant‐like effects in the forced swim test

The FASEB Journal, 2015
Dextromethorphan (DM) may serve as a safer alternative to ketamine as a fast acting antidepressant due to overlapping pharmacology. Our lab has previously shown DM produces antidepressant‐like effects through sigma‐1 (σ 1 ) receptors in the forced swim test (FST) in male Swiss, Webster mice ...
Anna Scandinaro, Linda Nguyen, Rae Matsumoto   +2 more
openaire   +1 more source

Evaluation of neurobiological and antioxidant effects of novel melatonin analogs in mice

Saudi Pharmaceutical Journal, 2020
Based on the pharmacophore model of melatonin (MT1) receptor, we recently synthesized a series of indole derivatives that showed anticonvulsant activity with low neurotoxicity and hepatotoxicity in rodents.
Jana Tchekalarova, Natasha Ivanova, Zlatina Nenchovska, Rumiana Tzoneva, Tzveta Stoyanova, Veselina Uzunova, Slavina Surcheva, Alex Tzonev, Violina T. Angelova, Pavlina Andreeva-Gateva   +9 more
doaj   +1 more source

Shumian capsule alleviates learning and memory impairment caused by chronic sleep deprivation in mouse models [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of Shumian capsule (SMC) on learning and memory impairment induced by chronic sleep deprivation and to explore its underlying mechanism.
HAN Songyan, LI Wenhua, ZHAO Haiqing, YAN Yan, LIU Yanyong, YANG Nan
doaj   +1 more source

Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt , Slc6a15 and Adora1 gene expression

Toxicology and Applied Pharmacology, 2017
Recent preclinical and clinical data suggest that low dose of caffeine enhances the effects of common antidepressants. Here we investigated the effects of chronic administration of caffeine (5mg/kg, twice daily for 14days) and its withdrawal on day 15th on the activity of per se ineffective doses of fluoxetine (5mg/kg) and escitalopram (2mg/kg) given ...
Szopa, Aleksandra, Urszula Doboszewska, Herbet, Mariola, Wośko, Sylwia, Wyska, Elżbieta, Świąder, Katarzyna, Serefko, Anna, Korga-Plewko, Agnieszka, Wlaź, Aleksandra, Wróbel, Andrzej, Ostrowska-Leśko, Marta, Terlecka, Joanna, Kanadys, Adam, Poleszak, Ewa, Dudka, Jarosław, Piotr Wiktor Wlaź   +15 more
  +8 more sources

Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities

Molecules, 2018
Novel thiadiazole derivatives were synthesized through the reaction of acetylated 2-aminothiadiazole and piperazine derivatives. The chemical structures of the compounds were clarified by Infrared Spectroscopy (IR), 1H Nuclear Magnetic Resonance ...
Nafiz Öncü Can, Özgür Devrim Can, Derya Osmaniye, Ümide Demir Özkay   +3 more
doaj   +1 more source