Results 91 to 100 of about 1,995 (245)

Unveiling the complexity of vaccine hesitancy: A narrative review focusing on dengue vaccination

Human Vaccines & Immunotherapeutics
Dengue vaccines face significant challenges, including safety concerns, which contribute to vaccine hesitancy. Addressing this complex issue requires targeted strategies to overcome existing barriers.
Rachata Charoenwisedsil, Saranath Lawpoolsri, Pinyo Rattanaumpawan, Daniel Y. T. Goh, Gerard T. Flaherty, Thundon Ngamprasertchai   +5 more
doaj   +1 more source

Summary of two economic models for dengue vaccine TAK-003 use in Puerto Rico [PDF]

04-Dengue-Kaul-508 ...

core  

Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection [PDF]

Introduction: Dengue virus infection is a global health problem lacking specific therapy, requiring an improved understanding of DENV immunity and vaccine responses. Considering the recent emerging of new dengue vaccines, here we performed an integrative
Baiocchi, Gabriela Crispim, Cabral-Marques, Otavio, Cabral-Miranda, Gustavo, Calich, Vera Lúcia Garcia, Camara, Niels Olsen Saraiva, Catar, Rusan, Filgueiras, Igor Salerno, Fonseca, Dennyson Leandro M., Freire, Paula Paccielli, Giil, Lasse M., Jurisica, Igor, Marques, Alexandre H. C., Moll, Guido, Ochs, Hans D., Plaça, Desirée Rodrigues, Prado, Caroline Aliane de Souza, Rivino, Laura, Rocha, Vanderson, Salgado, Ranieri Coelho, Schimke, Lena F., Usuda, Júlia Nakanishi, Zaki Pour, Shahab   +21 more
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Fe2+‐ Induced Activation of Single and Dual Metal Site—Lattice Oxygen Mechanism in Fe Rich NiFe‐LDHs for Oxygen Evolution Reaction

Advanced Science, EarlyView.
Fe‐rich NiFe‐LDH catalysts derived from MOFs, showing superior OER activity via lattice oxygen mechanism activation. ABSTRACT Developing a durable and efficient oxygen evolution reaction (OER) catalyst without noble metals is essential for the economical and sustainable production of hydrogen by alkaline water electrolysis.
Nithinraj Panangattu Dharmarajan, Mohammed Fawaz, Vanshree Parey, Sudip Chakraborty, CI Sathish, Thi Thuy Kieu Tran, Xuan Minh Chau Ta, Siddulu Naidu Talapaneni, Zhixuan Li, Kavitha Ramadass, Antonio Tricoli, Jae‐Hun Yang, Ajayan Vinu   +12 more
wiley   +1 more source

Symmetry in a multi-strain epidemiological model with distributed delay as a general cross-protection period and disease enhancement factor [PDF]

Important biological features of viral infectious diseases caused by multiple agents with interacting strain dynamics continue to pose challenges for mathematical modelling development. Motivated by dengue fever epidemiology, we study a system of Integro-
Aguiar, M., Oliva, S., Steindorf, V., Stollenwerk, N.   +3 more
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In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Mature dengue virus particles inactivated by a non-ionic detergent retain quaternary neutralizing epitopes and induce potent neutralizing antibodies [PDF]

Introduction: The four serotypes of dengue virus (DENV1-4) are the leading cause of arboviral diseases in humans. Currently, developing a safe and effective DENV vaccine remains a challenge.
Amonrat Jumnainsong, Gavin Screaton, James E. Crowe, Jens Wrammert, Juthathip Mongkolsapaya, Juthathip Mongkolsapaya, Theodore C. Pierson, Wanwisa Dejnirattisai, Wei-Kung Wang, Wen-Yang Tsai   +9 more
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Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Dengue dynamics: A holistic predictive model considering epidemic, vaccination, and environmental factors

Global Public Health
This research applied a predictive model to analyse the role that vaccination and community factors play in controlling the dengue virus. The study considers epidemiological and environmental data from the city of São Paulo (Brazil) after the start of ...
Wenru Wang, Hilal Atasoy, Yao Yao, Miklos Vasarhelyi, Henrique Tajiri, Fabricia Silva da Rosa, Ana Carolina da Costa, Gabriel Donadio Costa, Rogério João Lunkes, Vladimir Arthur Fey, Dayanni Nogueira Castro, Katiane Rodrigues Torres   +11 more
doaj   +1 more source