Results 241 to 250 of about 121,642 (290)

Cellulose Nanocrystal and Polymer Composite Microspheres for Methylene Blue Adsorption. [PDF]

Polymers (Basel)
Deng Y, Li Z, Wang R, Shi Y.
europepmc   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Evaluation of new quality productive forces in Henan province based on improved entropy weight-TOPSIS method and deep learning. [PDF]

Sci Rep
Jiang S.
europepmc   +1 more source

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source

Unveiling the Spatiotemporal Dynamics of Global Brain Circulation: A Comprehensive Corpus (2000-2024). [PDF]

Sci Data
Hu Z, Qiu Y, Jiang H, Ma X, Han L, Lei S, Niu H.   +6 more
europepmc   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Does urban density always boost smart productivity? Evidence of an inverted U-shaped relationship in Chinese cities. [PDF]

PLoS One
Chen T, Zhang Y, Yang Y, Wu B, Xu G.
europepmc   +1 more source

Highly Secure In Vivo DNA Data Storage Driven by Genomic Dynamics

Advanced Science, EarlyView.
Integrated computational‐biological programming enables secure in vivo data storage by generating code tables from either genomes or gene regulatory networks, expanding the encryption key space by over 100 orders of magnitude. Storing code tables within synthetic genes, genomes, or gene regulatory networks adds an additional layer of security by ...
Jiaxin Xu, Yu Wang, Haibo Zhou, Mingen Li, Yang Wang, Lingwei Wang, Hui Mei, Junbiao Dai, Shanze Chen, Xiaoluo Huang   +9 more
wiley   +1 more source

Female Starlings With Experimentally Impaired Pre-Laying Condition Produce Smaller But Vitamin A Richer Eggs. [PDF]

J Exp Zool A Ecol Integr Physiol
Casquero S, Redondo I, Gómez-Llanos E, Romero-Haro AÁ, Gil D, Pérez-Rodríguez L.   +5 more
europepmc   +1 more source

Explainable AI and echo state networks calibrate trust in human machine interaction. [PDF]

Sci Rep
Hao S, Teng F, Hou R, Zhang L, Wu H, Qi J.   +5 more
europepmc   +1 more source