Results 51 to 60 of about 3,155,872 (310)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Sliding benchmarks might prevent de-selection of talented badminton players

International Journal of Racket Sports Science
Despite potential advantages of talent identification practices, the degree of bias in decision-making due to relative age and maturity timing remains a concern.
Johan Pion, Mohd Rozilee Wazir Norjali Wazir, Irene Faber, Kathryn Johnston, Pieter Vansteenkiste, Matthieu Lenoir, Tengku-Fadilah Kamalden   +6 more
doaj   +1 more source

Performance Advantages of Left-Handed Cricket Batting Talent

Frontiers in Psychology, 2020
The purpose of this study was to examine performance advantages associated with batting stance, in the form of left- vs. right-handed dominant stance, and orthodox vs. reverse stance, of talented junior cricket batters within age-restricted competitions.
Jonathan D. Connor, David L. Mann, Miguel-Angel Gomez, Anthony S. Leicht, Kenji Doma   +4 more
doaj   +1 more source

Governing Talent Selection through the Brain: Constructing Cognitive Executive Function as a Way of Predicting Sporting Success

Sport, Ethics and Philosophy, 2019
An increasingly central part of the scientific debate in sports has come to focus on how neuroscience can help to explain sports performance and development of expertise.
Magnus Kilger, Helena Blomberg
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Talent Management - Case Study on Determining the Collective Pool of Talent [PDF]

Risk in Contemporary Economy, 2012
Our paper focuses on the importance of attracting and retaining talent in a company. Attracting talent refers not only to the selection of talented employees from outside the company, but also to their identification among existing employees by ...
Mirabela-Constanta MATEI, Annamaria RAKOCZI, Maria-Madela ABRUDAN   +2 more
doaj  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Talent Development in Young Cross-Country Skiers: Longitudinal Analysis of Anthropometric and Physiological Characteristics

Frontiers in Sports and Active Living, 2020
Introduction: Very little is known about talent development and selection processes in young cross-country skiers.Aim: (1) to analyze the effect of age on anthropometric and physiological parameters in medium-to-high level cross-country skiers during the
Chiara Zoppirolli, Chiara Zoppirolli, Roberto Modena, Roberto Modena, Alessandro Fornasiero, Alessandro Fornasiero, Lorenzo Bortolan, Lorenzo Bortolan, Spyros Skafidas, Aldo Savoldelli, Aldo Savoldelli, Federico Schena, Federico Schena, Barbara Pellegrini, Barbara Pellegrini   +14 more
doaj   +1 more source

Practical uses of genetic profile assessment in athletic training – an illustrative case study [PDF]

, 2014
Recent studies suggested that several potential genes may explain athletic success. However, while genetic assessment will probably become part of future talent identification, at present, genetic testing predictive value is poor, mainly because athletic
Ben-Zaken, Sigal, Dror, Nitzan, Eliakim, Alon, Meckel, Yoav, Nemet, Dan   +4 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source