Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Giftedness and allergy: A comparative study of the risk factors in gifted and typical children
Northwestern Medical JournalAim: To compare the various parameters associated with giftedness and allergy in gifted children within their group and with typical children of average intelligence. Methods: The case-control questionnaire study was conducted in Adıyaman, Türkiye, in
Erdoğan Öz +7 more
doaj +1 more source
South African Journal of Business Management, 2006 This research explores the formation of self-efficacy beliefs from the perspective of individual employees occupying formal work roles within the supply chain division of an international fruit-marketing organisation.
W. Anyster, S. Goodman, T. Wallis
doaj +1 more source
The national challenge: raising standards, supporting schools - overview of the gifted and talented pilot programme (National Strategies: national challenge) [PDF]
, 2009 "This is the first in a series of resources to be published by the National Strategies to help schools in this National Challenge pilot to accelerate the progress and enrich the learning of gifted and talented (G&T) pupils.
core
Optimising the learning of gifted aboriginal students [PDF]
, 2006 [Abstract]: According to the United Nations Educational, Scientific and Cultural Organisation's (2000) 'Education for All' goals, all students are entitled to opportunities to fulfil their potential.
Garvis, Susanne
core +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
The national challenge: raising standards, supporting schools - gifted and talented pilot programme. User guide and element 1: leading and managing improvement for gifted and talented education (National Strategies: national challenge) [PDF]
, 2009 "A booklet to help schools involved in the National Challenge Gifted and Talented (G&T) pilot to support leadership and management of improvement for gifted and talented education. This booklet contains Element 1 of a set of three.
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source