Results 141 to 150 of about 90,488 (249)

Pristimerin ameliorates spasmolytic polypeptide-expressing metaplasia by modulating <i>Cdkn1c</i> (p57)-mediated glycolytic reprogramming. [PDF]

World J Gastroenterol
Wen JS, Pan ZW, Yao XD, Liu YQ, Zhu YD.
europepmc   +1 more source

Discovery of Capsazepine as a Novel MCL1 Inhibitor for Overcoming Tamoxifen Resistance in Breast Cancer Therapy

eFood, Volume 7, Issue 2, April 2026.
MCL1 in promoting tamoxifen resistance by inhibiting apoptosis. This study demonstrates that the compound CPZ, identified through virtual screening and validated by molecular docking and experiments, directly binds to MCL1. This binding restores apoptosis and inhibits tumor growth, thereby combating resistance to endocrine therapy in breast cancer ...
Shujing Liu, Jiayin Li, Chengkun Wu, Yupeng Xiao, Jing Yu, Yu Xie, Chen Lin, Chunhua Liu, Yue Wang, Junfang Qin   +9 more
wiley   +1 more source

Pharmacotherapeutic considerations of selective estrogen receptor modulators for vascular protection. [PDF]

Front Pharmacol
Al Banna J, Karam F, Hassanieh D, Khanafer YH, Seed Ahmed M, Sharara H, Eid AH.   +6 more
europepmc   +1 more source

Laser and radiofrequency for treating genitourinary syndrome of menopause in breast cancer survivors: A systematic review of randomized controlled trial

International Journal of Gynecology &Obstetrics, Volume 173, Issue 1, Page 99-108, April 2026.
Abstract Background Breast cancer survivors (BCS) often experience more severe symptoms of genitourinary syndrome of menopause (GSM). As estrogen‐based hormonal therapy is generally avoided in BCS, physical energy methods may offer promising non‐hormonal alternatives.
Nicoli Serquiz, Ayane Cristine Alves Sarmento, Antonio Carlos Queiroz de Aquino, Natalie Rios Almeida, Maria Luísa Nobre, Juliana Dantas de Araújo Santos Camargo, Kleyton Santos de Medeiros, Ana Katherine Gonçalves   +7 more
wiley   +1 more source

Tamoxifen triggers a transcriptional switch from proliferation to differentiation in the circumvallate taste epithelium in mice. [PDF]

Sci Rep
Oura N, Koyanagi-Matsumura E, Hagimoto A, Saito M, Saijo H, Miura H.   +5 more
europepmc   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Sex-dependent effects of tamoxifen on mouse behavior. [PDF]

Behav Brain Funct
Xu RX, Liao SH, Wang N, Jiang WY, Wang X, Li XW, Gao TM, Yang JM.   +7 more
europepmc   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, Volume 183, Issue 8, Page 1640-1652, April 2026.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Identification of Resistance Genes in Breast Cancer Cells Treated with Fulvestrant and Ribociclib via Retroviral Screening and Integration Site Sequencing. [PDF]

Cells
Huang Z, Beaufort C, Helmijr J, Zantboer B, Rozema G, Muritti C, Whien JJ, Uijterwegen A, Massimino M, Martens JWM, Jansen MPHM.   +10 more
europepmc   +1 more source

Repeated Stress Escalates Aggression and Activity in Fronto‐Limbic Regions in Cntnap2−/− Mice

Genes, Brain and Behavior, Volume 25, Issue 2, April 2026.
Stress induced aggression emerges only after repeated restraint stress in Cntnap2−/− mice. Neuronal activity mapping revealed stress‐evoked activation in the lateral septum, lateral habenula, lateral hypothalamus, nucleus accumbens, and prefrontal cortex, with aggressive behavior positively correlating specifically with activity in the lateral septum ...
Caroline H. Hertweck, Chase A. Carter, Sarah S. McDaniel, Pierre Llorach, Hayleigh E. Tilton, Anish Kodali, Daniel J. Christoffel, Jessica J. Walsh   +7 more
wiley   +1 more source