This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen +10 more
wiley +1 more source
Estrogen Signaling During Abrupt Involution and Long-Term Metabolic Signature Similar to Estrogen Receptor-Negative Breast Cancer. [PDF]
Ormiston K +17 more
europepmc +1 more source
This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu +12 more
wiley +1 more source
Correction to "Ethanol-Extracted Cameroonian Propolis Counteracts Tamoxifen-Induced Endometrial Hyperplasia by Modulating Apoptosis and Proliferation-Regulating Proteins in Intact Wistar Rats". [PDF]
europepmc +1 more source
Severe retinopathy induced by low-dose tamoxifen: a 10-month follow-up analysis based on multimodal imaging. [PDF]
Zhang S +5 more
europepmc +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Micro/Nanorobot for Drug Delivery—A Review of Material Selections
This review explores material strategies for biomedical micro/nanorobots, emphasizing their roles in propulsion, navigation, drug delivery, and biodegradability. It highlights advancements in metallic, polymeric, and hybrid materials, while addressing clinical translation challenges such as toxicity, immune response, and manufacturability.
Xiaozhuo Wu, Bingyun Li, Malcolm Xing
wiley +1 more source
Interplay between AIB1 genotypes and radiotherapy in a Swedish population-based breast cancer cohort. [PDF]
Wiberg A +4 more
europepmc +1 more source
Targeting the melanocytes of the inner ear: A comparison of different CreER lines. [PDF]
Nayak MK +6 more
europepmc +1 more source
Breast Fibromatosis in a Patient With a History of Treated Breast Cancer: A Case Report
ABSTRACT Desmoid tumors are benign mesenchymal neoplasms that originate from muscular fasciae and aponeuroses. Breast involvement is exceptionally rare, accounting for less than 0.2% of all breast tumors. A 41‐year‐old woman with a history of right‐sided invasive ductal carcinoma (IDC) diagnosed in 2022 underwent breast‐conserving surgery (BCS) and ...
Saba Ebrahimian +2 more
wiley +1 more source

