Results 21 to 30 of about 90,488 (249)

Evaluation of the Method of Binding Tamoxifen to DNA Experimentally and Computationally [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021
Background and Aim: Tamoxifen is a group of drugs of selective estrogen receptor modulators, and is one of the drugs effective in the prevention and treatment of some cancers (such as breast cancer).
Fatemeh Sharafi Bajgan, Reza Safari , Maryam Nejat Dehkordi   +2 more
doaj   +1 more source

Tamoxifen Use in a Patient with Idiopathic Macular Telangiectasia Type 2

Case Reports in Ophthalmology, 2018
Crystalline deposits and neurosensory retinal cavitary changes can develop in both tamoxifen retinopathy and nonproliferative idiopathic macular telangiectasia type 2 (MacTel2).
Alice Behrens, Ahmed Sallam, John Pemberton, Sami Uwaydat   +3 more
doaj   +1 more source

Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury.

PLoS ONE, 2020
The tamoxifen-dependent Cre/lox system in transgenic mice has become an important research tool across all scientific disciplines for manipulating gene expression in specific cell types.
Nicole Pukos, Dana M McTigue
doaj   +1 more source

CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation

Molecular Therapy: Oncolytics, 2020
Endocrine therapy is a systemic therapy and has become the main treatment strategy for patients with estrogen receptor (ER)-positive breast cancer.
Jun Zhou, Kehao Le, Ming Xu, Jie Ming, Wen Yang, Qiulei Zhang, Linlin Lu, Zihan Xi, Shengnan Ruan, Tao Huang   +9 more
doaj   +1 more source

Plasma rich-platelet (PRP) potentially attenuates tamoxifen spermatogenic dysfunction in rat's model: sperm quality, histomorphometric, and apoptosis assessment [PDF]

Asia Pacific Journal of Medical Toxicology
Background: Tamoxifen induces testicular atrophy and azoospermia. Conversely, platelet-rich plasma (PRP) is a distinctive analog yield enriched with cytokines and growth factors for improving tissue regeneration.
Hossein Hamali, Fatemeh Masoumi, Behzad Baradaran, Gholamreza Hamidian   +3 more
doaj   +1 more source

The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation

BMC Pharmacology and Toxicology, 2022
Background Tamoxifen treatment may induce dysregulation of estrogen homeostasis, leading to the occurrence of related adverse reactions. However, the potential mechanisms are still unclear.
Zhixiang Hao, Jiahao Xu, Han Zhao, Wei Zhou, Zhao Liu, Shiqing He, Xiaoxing Yin, Bei Zhang, Zhongjian Wang, Xueyan Zhou   +9 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The response of anti-VEGF therapy and tamoxifen withdrawal of tamoxifen-induced cystoid macular edema in the same patient

BMC Ophthalmology, 2021
Background Numerous cases with ocular toxicity secondary to tamoxifen have been reported, and became more apparent with keratopathy, cataract, optic neuritis, macular holes, crystalline retinopathy with or without cystoid macular edema (CME). Withdrawing
Chuanyu Li, Jun Xiao, He Zou, Bo Yang, Lifu Luo   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Tamoxifen suppresses pancreatic β-cell proliferation in mice.

PLoS ONE, 2019
Tamoxifen is a mixed agonist/antagonist estrogen analogue that is frequently used to induce conditional gene deletion in mice using Cre-loxP mediated gene recombination.
Surl-Hee Ahn, Anne Granger, Matthew M Rankin, Carol J Lam, Aaron R Cox, Jake A Kushner   +5 more
doaj   +1 more source