Results 141 to 150 of about 42,124 (246)
Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis
International Journal of Cancer, Volume 159, Issue 3, Page 768-781, 1 August 2026.In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente +12 more
wiley +1 more source
Deciphering the Functional Mechanisms of eIF3f in Tumors and Exploring Targeted Therapies
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a critical component of the eIF3 complex and plays a pivotal role in diverse biological processes, including cell proliferation, apoptosis, adhesion, and transcriptional regulation.
Yujinpeng Hao +3 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 7, Page 1400-1413, July 2026.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract INTRODUCTION Alzheimer's disease (AD) can be caused by autosomal‐dominant familial Alzheimer's disease (FAD) mutations in amyloid precursor protein (APP) or presenilin‐1 and 2, which form an enzyme substrate complex. KAT5 binds to the APP intracellular domain.
Greg A Cary +15 more
wiley +1 more source
Early Myelination Supports the Establishment of Consistent Handedness
Glia, Volume 74, Issue 7, July 2026.Early compact myelin is essential for the establishment but not the maintenance of consistent paw preference in mice. Congenital myelin absence reduces lateralization and creates a leftward bias, underscoring a developmental role in shaping brain asymmetries. ABSTRACT Lateralization of brain functions, such as handedness, is thought to enhance cortical
Sharlen Moore +7 more
wiley +1 more source
Head &Neck, Volume 48, Issue 7, Page E70-E75, July 2026.ABSTRACT Background Cutaneous adnexal carcinomas are a very rare group of cancers arising from appendageal structures of the skin. More than half occur in the head and neck region. No standard treatments exist for metastatic disease. Methods A 48‐year‐old postmenopausal female presented with an enlarging scalp lesion.
Nilesh Kapoor +3 more
wiley +1 more source
Studies of tamoxifen resistance in breast cancer
, 2007 Oestrogen is one of the most important hormonal regulators and is known to play a key role in the development and growth of breast cancer. The majority of tumours have a hormone dependent growth, and this is indicated by the presence of oestrogen ...
Palmebäck Wegman, Pia
core
Molecular mechanisms of tamoxifen resistance in breast cancer
, 2020 The resistance to tamoxifen, a drug used in the adjuvant therapy for hormone sensitive breast cancer, represents a major clinical obstacle. Although various mechanisms leading to tamoxifen resistance have been described and intensively studied, a ...
Tomková, Veronika
core
International Journal of Cancer, Volume 159, Issue 1, Page 210-223, 1 July 2026.What's New? The CDK4/6 inhibitor ribociclib in combination with an endocrine‐based therapy has demonstrated significant progression‐free and overall survival benefits in patients with advanced/metastatic HR+/HER2‐ breast cancer in the pivotal MONALEESA trials.
Peter A. Fasching +20 more
wiley +1 more source
EGR3 and estrone are involved in the tamoxifen resistance and progression of breast cancer. [PDF]
J Cancer Res Clin Oncol, 2023 Xie Y +7 more
europepmc +1 more source