Results 81 to 90 of about 1,390,158 (355)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Effect of top cell absorber thickness and bifacial illumination on monolithic (Ag,Cu)(In,Ga)Se2/Si tandem solar cells

JPhys Energy
Wide bandgap (Ag,Cu)(In,Ga)Se _2 (ACIGSe) is a viable candidate as top cell absorber in tandem devices. In this work, we investigate monolithic two-terminal ACIGSe-Si tandem cells with a bandgap of 1.5 eV.
Julia Horstmann, Mario Hanser, Jana-Isabelle Polzin, Matthias Maiberg, Roland Scheer, Martin Hermle   +5 more
doaj   +1 more source

One-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents [PDF]

, 2017
An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described.
Luthra, Sajinder K., McRobbie, Graeme, Pimlott, Sally L., Sloan, Nikki L., Sutherland, Andrew   +4 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Remote functionalization by tandem radical chain reactions [PDF]

, 1997
Normal radical relay chlorination of cholestan-3α-ol directed by an attached m-iodobenzoate ester group affords a 9α-chloro steroid, but when the same reaction is conducted in the presence of an excess of CBr4 the product is a 9α-bromo steroid ...
Wiedenfeld, David
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Research on Flow-Induced Vibration and Energy Harvesting of Three Circular Cylinders with Roughness Strips in Tandem

Energies, 2018
The flow-induced vibration (FIV) of multiple cylinders is a common phenomenon in industry and nature. The FIV and energy harvesting of three circular cylinders in tandem are numerically studied by 2D-URANS simulations in Reynolds number range of 30,000 ...
Lin Ding, Qunfeng Zou, Li Zhang, Haibo Wang   +3 more
doaj   +1 more source

Rapid method for Mycobacterium tuberculosis identification using electrospray ionization tandem mass spectrometry analysis of mycolic acids [PDF]

, 2013
Mycolic acids (MAs), which play a crucial role in the architecture of mycobacterial cell walls, were analyzed using electrospray ionization tandem mass spectrometry. A targeted analysis based on the 10 most abundant and characteristic multiple reaction
Beata Janiszewska-Drobinska, Behr, Beukes, Brennan, Butler, Centers for Disease Control & Prevention (CDC), Chang, Daley, Deng, Dorman, Drobniewski, El Khéchine, Fujiwara, Jafari, Konrad Kowalski, Kowalski, Lawn, Lotz, Magdalena Druszczyńska, Ottenhoff, Park, Rafał Szewczyk, Saleeb, Schluger, Shitikov, Shui, Shui, Siddiqi, Song, Steingart, Takayama, Toney, Tostmann, Viader-Salvadó, Vittor, Wang, World Health Organization (WHO), Yassin, Yuan   +38 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Le tandem au service de l’intégration académique [PDF]

Synergies Portugal, 2019
Le Centre de Langues de l’Université du Luxembourg propose chaque semestre des cours et ponctuellement des événements multilingues dans les trois langues officielles de l’université : le français, l’allemand et l’anglais.
Ève Lejot, Leslie Molostof
doaj