Results 61 to 70 of about 671,203 (335)

Mechanism of tandem duplication formation in BRCA1 mutant cells

Nature, 2017
Small, approximately 10-kilobase microhomology-mediated tandem duplications are abundant in the genomes of BRCA1-linked but not BRCA2-linked breast cancer. Here we define the mechanism underlying this rearrangement signature.
Nicholas A. Willis, Richard L. Frock, F. Menghi, Erin E. Duffey, Arvind Panday, Virginia Camacho, P. Hasty, E. Liu, F. Alt, R. Scully   +9 more
semanticscholar   +1 more source

Profiling of gene duplication patterns of sequenced teleost genomes: evidence for rapid lineage-specific genome expansion mediated by recent tandem duplications

BMC Genomics, 2012
Background Gene duplication has had a major impact on genome evolution. Localized (or tandem) duplication resulting from unequal crossing over and whole genome duplication are believed to be the two dominant mechanisms contributing to vertebrate genome ...
Lu Jianguo, Peatman Eric, Tang Haibao, Lewis Joshua, Liu Zhanjiang   +4 more
doaj   +1 more source

Tandem quadruplication of HMA4 in the zinc (Zn) and cadmium (Cd) hyperaccumulator Noccaea caerulescens. [PDF]

PLoS ONE, 2011
Zinc (Zn) and cadmium (Cd) hyperaccumulation may have evolved twice in the Brassicaceae, in Arabidopsis halleri and in the Noccaea genus. Tandem gene duplication and deregulated expression of the Zn transporter, HMA4, has previously been linked to Zn/Cd ...
Seosamh Ó Lochlainn, Helen C Bowen, Rupert G Fray, John P Hammond, Graham J King, Philip J White, Neil S Graham, Martin R Broadley   +7 more
doaj   +1 more source

Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas [PDF]

, 2018
Pilocytic astrocytomas represent the most common glioma subtype in young patients and account for 5.4% of all gliomas. They are characterized by alterations in the RAS–MAP kinase pathway, the most frequent being a tandem duplication on chromosome 7q34 ...
Appay, Romain, Badiali, Manuela, Barets, Doriane, Colin, Carole, Figarella-Branger, Dominique, Fina, Frédéric, Giangaspero, Felice, Korshunov, Andrey, M. Pfister, Stefan, Macagno, Nicolas, Ordioni, Joanna, Padovani, Laëtitia, Scavarda, Didier, T. W. Jones, David   +13 more
core   +3 more sources

Chromosome mapping of dragline silk genes in the genomes of widow spiders (araneae, theridiidae) [PDF]

, 2010
With its incredible strength and toughness, spider dragline silk is widely lauded for its impressive material properties. Dragline silk is composed of two structural proteins, MaSp1 and MaSp2, which are encoded by members of the spidroin gene family ...
Ayoub, NA, Hayashi, CY, Zhao, Y
core   +3 more sources

TD-COF: A new method for detecting tandem duplications in next generation sequencing data

SoftwareX
Tandem duplications significantly influence the diversity of the human genome and the occurrence of many complex diseases. However, accurate detection of tandem duplications of low coverage remains a challenging task. Based on RD (read depth), the tandem
Daicong Jia, Jinxin Dong, Hua Jiang, Zuyao Zhao, Xilong Jiang   +4 more
doaj   +1 more source

Validation of the 2017 European LeukemiaNet classification for acute myeloid leukemia with NPM1 and FLT3‐internal tandem duplication genotypes

Cancer, 2018
The revised 2017 European LeukemiaNet (ELN) classification (ELN‐2017) of acute myeloid leukemia (AML) divides patients into 3 prognostic risk categories, with additional factors such as the fms‐like tyrosine kinase 3 (FLT3)–internal tandem duplication ...
P. Boddu, T. Kadia, G. Garcia-Manero, J. Cortes, M. Alfayez, G. Borthakur, M. Konopleva, E. Jabbour, N. Daver, C. Dinardo, K. Naqvi, M. Yilmaz, N. Short, S. Pierce, H. Kantarjian, F. Ravandi   +15 more
semanticscholar   +1 more source

Identification of Duplication Genotypes of the Feathering Rate Gene in Chicken by a Multiplex PCR Following Electrophoresis and/or Sanger Sequencing

Animals, 2023
Sex-linked phenotypes of late feathering (LF) and early feathering (EF) are controlled by a pair of alleles K and k+. Autosexing based on the feathering rate is widely used in poultry production.
Qingmiao Shen, Junying Li, Haigang Bao, Changxin Wu   +3 more
doaj   +1 more source

Genome-Wide Analysis of MIKC^C-Type MADS-Box Genes Reveals Their Involvement in Flower Development in Malus Lineage

Horticulturae, 2023
MIKCC-type MADS-box genes are involved in floral organ identity determination but remain less studied in the Malus lineage. Based on the conserved domains of this gene family, we identified 341 genes among 13 species.
Kun Ning, Wangxiang Zhang, Donglin Zhang, Yousry A. El-Kassaby, Ting Zhou   +4 more
doaj   +1 more source

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers [PDF]

, 2017
Somatic rearrangements contribute to the mutagenized landscape of cancer genomes. Here, we systematically interrogated rearrangements in 560 breast cancers by using a piecewise constant fitting approach.
Alexandrov, L.B. (Ludmil), Birney, E. (Ewan), Borresen-Dale, A.-L. (Anne-Lise), Brinkman, A.B. (Arie B.), Campbell, P.J. (Peter), Davies, H. (Helen), Diez-Perez, J. (Javier), Easton, D.F. (Douglas), Evan, G. (Gerard), Glodzik, D. (Dominik), Kong, G. (Gu), Lakhani, S. (Sunil), Li, Y. (Yilong), Martens, J.W.M. (John), Morganella, S. (Sandro), Nik-Zainal, S. (Serena), Purdie, C.A. (Colin A.), Raine, (Keiran), Richardson, A.L. (Andrea), Russnes, H. (Hege), Rye, I.H. (Inga Hansine), Simpson, P.T. (Peter T.), Smid, M. (Marcel), Staaf, J. (Johan), Stratton, M.R. (Michael R.), Stunnenberg, H. (Henk), Thompson, A.M. (Alastair M.), Viari, A. (Alain), Vijver, M.J. (Marc ), Zou, X. (Xueqing)   +29 more
core   +1 more source