Results 71 to 80 of about 887,704 (273)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Extending the TerraSAR-X Ground Segment for TanDEM-X [PDF]
, 2010 This paper describes selected areas in which the TerraSAR-X ground segment had to be extended in order to incorporate the TanDEM-X mission, namely flight dynamics, instrument operations and receiving stations and addresses their ...
Steinbrecher, Ulrich +5 more
core
IHJ Cardiovascular Case Reports, 2019 Tandem and/or diffuse calcific coronary stenoses can present significant challenges during percutaneous coronary intervention (PCI). Often, these long lesions require treatment with multiple stents of different calibers. However, this approach can result
Baskar Sekar +2 more
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
TanDEM-X: Mission Concept, Product Definition and Performance Prediction [PDF]
, 2006 This paper gives a short overview of the TanDEM-X mission concept, summarizes the basic products, illustrates the achievable performance, and gives some examples for new imaging ...
Werner, Marian +6 more
core
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Molecules, 2020 Oxidatively generated damage to DNA frequently appears in the human genome as the effect of aerobic metabolism or as the result of exposure to exogenous oxidizing agents, such as ionization radiation.
Bolesław T. Karwowski
doaj +1 more source
Non-nominal Experimental Bistatic SAR Acquisitions with TanDEM-X [PDF]
, 2012 TanDEM-X is a high-resolution interferometric mission with the main goal of providing a global and unprecedentedly accurate digital elevation model (DEM) of the Earth surface by means of single-pass X-band SAR interferometry.
Schulze, Daniel +10 more
core
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source