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Science, 1981
Coupling mass spectrometers in series provides a new technique that has many advantages for the analysis of specific organic compounds in complex mixtures. Sensitivity to picograms of targeted compounds can be achieved with high specificity and nearly instantaneous response.
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Coupling mass spectrometers in series provides a new technique that has many advantages for the analysis of specific organic compounds in complex mixtures. Sensitivity to picograms of targeted compounds can be achieved with high specificity and nearly instantaneous response.
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Tandem Mass Spectrometry in Physiology
Physiology, 2007Tandem mass spectrometry coupled to liquid chromatography (LC-MS/MS) allows identification of proteins in a complex mixture without need for protein purification (“shotgun” proteomics). Recent progress in LC-MS/MS-based quantification, phosphoproteomic analysis, and targeted LC-MS/MS using multiple reaction monitoring (MRM) has made LC-MS/MS a powerful
Trairak, Pisitkun +3 more
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Tandem mass spectrometry — The potential
Journal of Inherited Metabolic Disease, 1999AbstractWe summarize the current status of the use of tandem mass spectrometry for the detection of inherited metabolic disorders and the investigation of the pathophysiology of these conditions. We also indicate some of the more recent developments of this technology that have potential diagnostic applications.
K, Bartlett, M, Pourfarzam
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Mass Spectrometry and Tandem Mass Spectrometry of Citrus Limonoids
Analytical Chemistry, 2003Methods for atmospheric pressure chemical ionization tandem mass spectrometry (APCI-MS/MS) of citrus limonoid aglycones and electrospray ionization tandem mass spectrometry (ESI-MS/MS) of limonoid glucosides are reported. The fragmentation patterns of four citrus limonoid aglycones (limonin, nomilin, obacunone, and deacetylnomilin) and six limonoid ...
Qingguo, Tian, Steven J, Schwartz
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2019
This chapter highlights the basic principles of ion fragmentation in a mass spectrometer and examines the methods used to induce dissociation. It describes the common tandem mass spectrometer designs and explains the experiments they make possible. It also mentions electron ionization (EI) as one of the methods of ionization that impart sufficient ...
James McCullagh, Neil Oldham
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This chapter highlights the basic principles of ion fragmentation in a mass spectrometer and examines the methods used to induce dissociation. It describes the common tandem mass spectrometer designs and explains the experiments they make possible. It also mentions electron ionization (EI) as one of the methods of ionization that impart sufficient ...
James McCullagh, Neil Oldham
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2003
For more than 30 years, electron ionization mass spectrometry (EIMS) has played a key role in the structural determination of small biological compounds, largely because it has three advantages to offer: very high sensitivity compared to other structural methods, such as nuclear magnetic resonance and infrared spectrometry, the possibility for analysis
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For more than 30 years, electron ionization mass spectrometry (EIMS) has played a key role in the structural determination of small biological compounds, largely because it has three advantages to offer: very high sensitivity compared to other structural methods, such as nuclear magnetic resonance and infrared spectrometry, the possibility for analysis
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Tandem mass spectrometry of amidated peptides
Journal of Mass Spectrometry, 2006AbstractThe behavior of C‐terminal amidated and carboxylated peptides upon low‐energy collision‐induced dissociation (CID) was investigated. Two sets of 76 sequences of variable amino acid compositions and lengths were synthesized as model compounds.
Mouls, Laetitia +4 more
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Tandem mass spectrometry of synthetic polymers
Journal of Mass Spectrometry, 2009AbstractThe detailed characterization of macromolecules plays an important role for synthetic chemists to define and specify the structure and properties of the successfully synthesized polymers. The search for new characterization techniques for polymers is essential for the continuation of the development of improved synthesis methods.
Crecelius, A.C. +2 more
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Peptide quantification by tandem mass spectrometry
Mass Spectrometry Reviews, 1996This manuscript reviews the literature on the mass spectrometry (MS) and tandem mass spectrometry (MS/MS) quantification of biologically important peptides that have been extracted from tissues. The most important aspect of this quantification process is the use of MS/MS to link the protonated molecule ion, (M + H)(+) , of the peptide with one or more ...
X, Zhu, D M, Desiderio
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