Results 21 to 30 of about 136,753 (311)

Rediscovering tandem repeat variation in schizophrenia: challenges and opportunities

Translational Psychiatry, 2023
Tandem repeats (TRs) are prevalent throughout the genome, constituting at least 3% of the genome, and often highly polymorphic. The high mutation rate of TRs, which can be orders of magnitude higher than single-nucleotide polymorphisms and indels ...
Rebecca Birnbaum
doaj   +1 more source

Tandem repeats of the 5′ flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression

Biochemistry and Biophysics Reports, 2019
MUC5AC is a well-known gastric differentiation marker, which has been frequently used for the classification of stomach cancer. However, the molecular mechanism of regulation of MUC5AC expression remains to be elucidated.
Natsuko Kageyama-Yahara, Nobutake Yamamichi, Yu Takahashi, Chihiro Takeuchi, Yuta Matsumoto, Yoshiki Sakaguchi, Kazuhiko Koike   +6 more
doaj   +1 more source

Insertion of ten amino acids into 13S globulin zero-repeat subunit improves trypsin digestibility in common buckwheat (Fagopyrum esculentum Moench) seeds

Food Chemistry: Molecular Sciences, 2023
The 13S globulin zero-repeat subunit is resistant to trypsin and may have higher allergenicity than the 1–6 tandem repeat subunits in common buckwheat (Fagopyrum esculentum Moench).
Takeyuki Okada, Fakhrul Islam Monshi, Syuto Kudo, Tomoyuki Katsube-Tanaka   +3 more
doaj   +1 more source

Genetic Diversity and Genotype Distribution of Erwinia amylovora in Korea [PDF]

The Plant Pathology Journal
Erwinia amylovora, first identified in 1793 in Hudson Valley (New York, USA), has a genome size of 3.7–4.0 Mb. E. amylovora bacterial strains are classified based on the infecting hosts: the Amygdaloideae-infecting (AI) group, targeting apple and pear ...
Hyeonheui Ham, Se-Weon Lee, Yong Hwan Lee   +2 more
doaj   +1 more source

Gene–Environment Interactions in Repeat Expansion Diseases: Mechanisms of Environmentally Induced Repeat Instability

Biomedicines, 2023
Short tandem repeats (STRs) are units of 1–6 base pairs that occur in tandem repetition to form a repeat tract. STRs exhibit repeat instability, which generates expansions or contractions of the repeat tract.
Stephanie Calluori, Rebecca Stark, Brandon L. Pearson   +2 more
doaj   +1 more source

TROLL—Tandem Repeat Occurrence Locator [PDF]

Bioinformatics, 2002
Abstract Summary: Tandem Repeat Occurrence Locator (TROLL), is a light-weight Simple Sequence Repeat (SSR) finder based on a slight modification of the Aho–Corasick algorithm. It is fast and only requires a standard Personal Computer (PC) to operate.
Adalberto T, Castelo, Wellington, Martins, Guang R, Gao   +2 more
openaire   +2 more sources

Evolution and control of imprinted FWA genes in the genus Arabidopsis. [PDF]

PLoS Genetics, 2008
A central question in genomic imprinting is how a specific sequence is recognized as the target for epigenetic marking. In both mammals and plants, imprinted genes are often associated with tandem repeats and transposon-related sequences, but the role of
Ryo Fujimoto, Yuki Kinoshita, Akira Kawabe, Tetsu Kinoshita, Kazuya Takashima, Magnus Nordborg, Mikhail E Nasrallah, Kentaro K Shimizu, Hiroshi Kudoh, Tetsuji Kakutani   +9 more
doaj   +1 more source

RNA biology of disease-associated microsatellite repeat expansions

Acta Neuropathologica Communications, 2017
Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome and have important roles in genome evolution and function. However, the expansion of microsatellites is associated with over two dozen neurological diseases. A common
Kushal J. Rohilla, Keith T. Gagnon
doaj   +1 more source

The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium.

PLoS ONE, 2014
The circumsporozoite protein (CSP) is the major surface protein of the sporozoite stage of malaria parasites and has multiple functions as the parasite develops and then migrates from the mosquito midgut to the mammalian liver.
David J P Ferguson, Amanda E Balaban, Eva-Maria Patzewitz, Richard J Wall, Christine S Hopp, Benoit Poulin, Asif Mohmmed, Pawan Malhotra, Alida Coppi, Photini Sinnis, Rita Tewari   +10 more
doaj   +1 more source

Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs

Nature Communications, 2021
Variable number tandem repeats (VNTRs) are difficult to analyze by short-read sequencing in disease studies. Here, the authors describe a VNTR mapping strategy for short-read analyses using a repeat pangenome graph.
Tsung-Yu Lu, The Human Genome Structural Variation Consortium, Mark J. P. Chaisson   +2 more
doaj   +1 more source