Results 211 to 220 of about 87,488 (261)

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Comparative genomics and phylogenetic analysis of seven <i>Ficus</i> species based on chloroplast genomes. [PDF]

PeerJ
Bao S, Deng L, Shi Y, Duan N.
europepmc   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

Advanced Science, EarlyView.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou, Danfeng Cai, Changbin Zhao, Siyu Zhang, Jiahao Li, Zhaofeng Zhang, Shaofen Kong, Xin Yang, Xiaoli Zhou, Farhad Bordbar, Fayi Chen, Yaohuan Xu, Zhe Zhang, Lihong Gu, Zhenhui Li, Xiquan Zhang, Wen Luo, Jingting Shu, Bolin Cai, Qinghua Nie   +19 more
wiley   +1 more source

Genome-wide characterization of lumpy skin disease virus isolate from Bangladesh. [PDF]

Sci Rep
Uddin MB, Begum R, Paul JK, Rahman MM, Cho HS, Hossain MM.   +5 more
europepmc   +1 more source

Structural evolution of the whole mitochondrial genome and phylogenetic inference in snakes (Squamata: Serpentes), including the undescribed mitogenome of the Brazilian endemic and critically endangered pitviper Bothrops insularis. [PDF]

Genet Mol Biol
Salles-Oliveira I, Patané JSL, Nishiyama-Júnior MY, Silva MJJ.   +3 more
europepmc   +1 more source

Updated Erdman reveals tandem repeat copy number is phase-variable and impacts <i>M. tuberculosis</i> adaptation across evolutionary timescales. [PDF]

mSystems
Modlin SJ, Thosar N, Mejía-Ponce PM, Lunceford RL, Makafe GG, Weinrick B, Valafar F.   +6 more
europepmc   +1 more source

Targeting surface cell antigen 2 increases sensitivity of Rickettsia typhi detection. [PDF]

PLoS Negl Trop Dis
Phuklia W, Padith K, Phommasone K, Chansamouth V, Mayxay M, Vongphachanh S, Newton PN, Robinson MT, Ashley EA.   +8 more
europepmc   +1 more source

The genome of Phlebotomus chinensis, the primary vector of visceral leishmaniasis in China: insights from chromosome-level assembly and comparative analysis. [PDF]

Infect Dis Poverty
Dong H, Shan W, Zhou Q, Yuan H, Wang K, Li Y, Zhong W, Wumaier M, Yang A, Chen H, Rui B, Ma Y, Li S, Peng H.   +13 more
europepmc   +1 more source

High-resolution genome assembly reveals retrotransposon-mediated centromere dynamics in rye. [PDF]

Genome Biol
Yi C, Liu Q, Zhu C, Liu C, Zhou C, He W, Wang C, Yuan J, Liu Y, Han F.   +9 more
europepmc   +1 more source