Results 31 to 40 of about 87,488 (261)
Repetitive Elements in Mycoplasma hyopneumoniae Transcriptional Regulation. [PDF]
PLoS ONE, 2016 Transcriptional regulation, a multiple-step process, is still poorly understood in the important pig pathogen Mycoplasma hyopneumoniae. Basic motifs like promoters and terminators have already been described, but no other cis-regulatory elements have ...
Amanda Malvessi Cattani +3 more
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Nanopore Sequencing Resolves Elusive Long Tandem-Repeat Regions in Mitochondrial Genomes [PDF]
International Journal of Molecular Sciences, 2021 Long non-coding, tandem-repetitive regions in mitochondrial (mt) genomes of many metazoans have been notoriously difficult to characterise accurately using conventional sequencing methods. Here, we show how the use of a third-generation (long-read) sequencing and informatic approach can overcome this problem.
Liina Kinkar +8 more
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RNA biology of disease-associated microsatellite repeat expansions
Acta Neuropathologica Communications, 2017 Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome and have important roles in genome evolution and function. However, the expansion of microsatellites is associated with over two dozen neurological diseases. A common
Kushal J. Rohilla, Keith T. Gagnon
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IMPACT OF TANDEM REPEATS ON THE SCALING OF NUCLEOTIDE SEQUENCES [PDF]
International Journal of Bifurcation and Chaos, 2006 Techniques such as detrended fluctuation analysis (DFA) and its extensions have been widely used to determine the nature of scaling in nucleotide sequences. In this brief communication we show that tandem repeats which are ubiquitous in nucleotide sequences can prevent reliable estimation of possible long-range correlations. Therefore, it is important
Nagarajan, Radhakrishnan +1 more
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Tandem repeats finder: a program to analyze DNA sequences [PDF]
Nucleic Acids Research, 1999 A tandem repeat in DNA is two or more contiguous, approximate copies of a pattern of nucleotides. Tandem repeats have been shown to cause human disease, may play a variety of regulatory and evolutionary roles and are important laboratory and analytic tools. Extensive knowledge about pattern size, copy number, mutational history, etc. for tandem repeats
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Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequences [PDF]
Genome Research, 2010 The centromere is essential for faithful chromosome segregation by providing the site for kinetochore assembly. Although the role of the centromere is conserved throughout evolution, the DNA sequences associated with centromere regions are highly divergent among species and it remains to be determined how centromere DNA directs kinetochore formation ...
Wei-Hao, Shang +7 more
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Intragenic tandem repeat variation between
BMC Microbiology, 2008 Background Bacterial genomes harbour a large number of tandem repeats, yet the possible phenotypic effects of those found within the coding region of genes are only beginning to be examined.
Jarraud Sophie +5 more
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Bio-Protocol, 2022 Repeat expansion diseases, including fragile X syndrome, Huntington’s disease, and C9orf72-related motor neuron disease and frontotemporal dementia, are a group of disorders associated with polymorphic expansions of tandem repeat nucleotide sequences ...
Joanne Sharpe, Nikki Harper, Ryan West
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Variable Tandem Repeats Accelerate Evolution of Coding and Regulatory Sequences
Annual Review of Genetics, 2010 Genotype-to-phenotype mapping commonly focuses on two major classes of mutations: single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we discuss an underestimated third class of genotypic variation: changes in microsatellite and minisatellite repeats.
Gemayel, Rita +3 more
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Tandem Repeats Contribute to Coding Sequence Variation in Bumblebees (Hymenoptera: Apidae) [PDF]
Genome Biology and Evolution, 2017 AbstractTandem repeats (TRs) are highly dynamic regions of the genome. Mutations at these loci represent a significant source of genetic variation and can facilitate rapid adaptation. Bumblebees are important pollinating insects occupying a wide range of habitats.
Xiaomeng Zhao +4 more
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