Variable Tandem Repeats Accelerate Evolution of Coding and Regulatory Sequences
Annual Review of Genetics, 2010 Genotype-to-phenotype mapping commonly focuses on two major classes of mutations: single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we discuss an underestimated third class of genotypic variation: changes in microsatellite and minisatellite repeats.
Gemayel, Rita +3 more
openaire +3 more sources
Tandem Repeats Contribute to Coding Sequence Variation in Bumblebees (Hymenoptera: Apidae) [PDF]
Genome Biology and Evolution, 2017 AbstractTandem repeats (TRs) are highly dynamic regions of the genome. Mutations at these loci represent a significant source of genetic variation and can facilitate rapid adaptation. Bumblebees are important pollinating insects occupying a wide range of habitats.
Xiaomeng Zhao +4 more
openaire +2 more sources
Sunflower centromeres consist of a centromere-specific LINE and a chromosome-specific tandem repeat
Frontiers in Plant Science, 2015 The kinetochore is a protein complex including kinetochore-specific proteins that plays a role in chromatid segregation during mitosis and meiosis. The complex associates with centromeric DNA sequences that are usually species-specific. In plant species,
Kiyotaka eNagaki +4 more
doaj +1 more source
Multiple Locus Variable number of tandem repeat Analysis : a molecular genotyping tool for Paenibacillus larvae [PDF]
, 2016 American Foulbrood, caused by Paenibacillus larvae, is the most severe bacterial disease of honey bees (Apis mellifera). To perform genotyping of P.larvae in an epidemiological context, there is a need of a fast and cheap method with a high resolution ...
Alippi +40 more
core +2 more sources
Straglr: discovering and genotyping tandem repeat expansions using whole genome long-read sequences
Genome Biology, 2021 Tandem repeat (TR) expansion is the underlying cause of over 40 neurological disorders. Long-read sequencing offers an exciting avenue over conventional technologies for detecting TR expansions.
Readman Chiu +3 more
doaj +1 more source
Evolution of Tandem Repeats Is Mirroring Post-polyploid Cladogenesis in Heliophila (Brassicaceae)
Frontiers in Plant Science, 2021 The unigeneric tribe Heliophileae encompassing more than 100 Heliophila species is morphologically the most diverse Brassicaceae lineage. The tribe is endemic to southern Africa, confined chiefly to the southwestern South Africa, home of two biodiversity
Mert Dogan +16 more
doaj +1 more source
Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]
, 2016 Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
A Ellahi +56 more
core +1 more source
Detecting Expansions of Tandem Repeats in Cohorts Sequenced with Short-Read Sequencing Data [PDF]
The American Journal of Human Genetics, 2018 Repeat expansions cause more than 30 inherited disorders, predominantly neurogenetic. These can present with overlapping clinical phenotypes, making molecular diagnosis challenging. Single-gene or small-panel PCR-based methods can help to identify the precise genetic cause, but they can be slow and costly and often yield no result.
Tankard, R.M. +5 more
openaire +2 more sources
Biochemistry and Biophysics Reports, 2019 MUC5AC is a well-known gastric differentiation marker, which has been frequently used for the classification of stomach cancer. However, the molecular mechanism of regulation of MUC5AC expression remains to be elucidated.
Natsuko Kageyama-Yahara +6 more
doaj +1 more source
Identification of tandem repeat families from long-read sequences of Humulus lupulus.
PLoS ONE, 2020 Hop (Humulus lupulus L.) is known for its use as a bittering agent in beer and has a rich history of cultivation, beginning in Europe and now spanning the globe.
Katherine A Easterling +7 more
doaj +1 more source