Results 61 to 70 of about 253,337 (321)

Multiple-locus variable-number tandem-repeat analysis of the swine dysentery pathogen, Brachyspira hyodysenteriae

, 2010
The spirochete Brachyspira hyodysenteriae is the causative agent of swine dysentery, a severe colonic infection of pigs that has a considerable economic impact in many swine-producing countries.
Rubio, P., Phillips, N.D., Ana Carvajal, Hidalgo, A., Germán Naharro, Tom La, Hampson, D.J., Álvaro Hidalgo, Pedro Rubio, Carvajal, A., La, T., David J. Hampson, Naharro, G., Nyree D. Phillips   +13 more
core   +1 more source

Unraveling tandem repeat variation in personal genomes with long reads [PDF]

, 2021
Tandem repeats are repeated sequences that occur adjacent to each other in the human genome. Due to their prevalence and their association with a number of genetic diseases, there is a rising interest in developing tools for tandem repeat profiling ...
Bolognini, Davide
core   +1 more source

Variable Tandem Repeats Accelerate Evolution of Coding and Regulatory Sequences

Annual Review of Genetics, 2010
Genotype-to-phenotype mapping commonly focuses on two major classes of mutations: single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we discuss an underestimated third class of genotypic variation: changes in microsatellite and minisatellite repeats.
Gemayel, Rita, Vinces, Marcelo, Legendre, Matthieu, Verstrepen, Kevin   +3 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Differentially Amplified Repetitive Sequences Among Aegilops tauschii Subspecies and Genotypes

Frontiers in Plant Science, 2021
Genomic repetitive sequences commonly show species-specific sequence type, abundance, and distribution patterns, however, their intraspecific characteristics have been poorly described.
Rahman Ebrahimzadegan, Fatemeh Orooji, Pengtao Ma, Ghader Mirzaghaderi   +3 more
doaj   +1 more source

Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs

Nature Communications, 2020
Variable number tandem repeats (VNTRs) are composed of consecutive repetitive DNA with hypervariable repeat count and composition. They include protein coding sequences and associations with clinical disorders.
Tsung-Yu Lu, Katherine M. Alexandra P. Qihui Luke J. Scott E. Charles Eva Munson Lewis Zhu Tallon Devine Lee Eichler, Katherine M. Munson, Alexandra P. Lewis, Qihui Zhu, L. Tallon, S. Devine, Charles Lee, Evan E. Eichler, Mark J. P. Chaisson   +9 more
semanticscholar   +1 more source

Diversity in coding tandem repeats in related Neisseria spp.

, 2003
This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL - © 2003 Jordan et al; licensee BioMed Central Ltd ...
Jordan, P, Snyder, Lori A S, Snyder, Lori, Snyder, LAS, Saunders, Nigel, Lori AS Snyder, Saunders, NJ, Jordan Philip, Snyder, LA, Jordan, Philip, Philip Jordan, Saunders Nigel J, Nigel J Saunders, Saunders, Nigel J, Snyder Lori AS   +14 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures

Nucleic Acids Res., 2020
The RepeatsDB database (URL: https://repeatsdb.org/) provides annotations and classification for protein tandem repeat structures from the Protein Data Bank (PDB). Protein tandem repeats are ubiquitous in all branches of the tree of life.
L. Paladin, Martina Bevilacqua, Sara Errigo, D. Piovesan, I. Mičetić, M. Necci, A. Monzon, M. L. Fabre, J. L. López, J. Nilsson, Javier Ríos, P. Menna, Maia Cabrera, Martín González Buitrón, M. G. Kulik, S. Alberti, M. Fornasari, G. Parisi, A. Lagares, L. Hirsh, Miguel Andrade, A. Kajava, Silvio C. E. Tosatto   +22 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source