Results 61 to 70 of about 177,651 (293)

TRiCoLOR: tandem repeat profiling using whole-genome long-read sequencing data [PDF]

GigaScience, 2020
Abstract Background Tandem repeat sequences are widespread in the human genome, and their expansions cause multiple repeat-mediated disorders. Genome-wide discovery approaches are needed to fully elucidate their roles in health and disease, but resolving tandem repeat variation accurately remains a ...
Davide Bolognini, Alberto Magi, Vladimir Benes, Jan O Korbel, Tobias Rausch   +4 more
openaire   +2 more sources

Differentially Amplified Repetitive Sequences Among Aegilops tauschii Subspecies and Genotypes

Frontiers in Plant Science, 2021
Genomic repetitive sequences commonly show species-specific sequence type, abundance, and distribution patterns, however, their intraspecific characteristics have been poorly described.
Rahman Ebrahimzadegan, Fatemeh Orooji, Pengtao Ma, Ghader Mirzaghaderi   +3 more
doaj   +1 more source

A new multi locus variable number of tandem repeat analysis scheme for epidemiological surveillance of Xanthomonas vasicola pv. musacearum, the plant pathogen causing bacterial wilt on banana and enset [PDF]

, 2019
Xanthomonas vasicola pv. musacearum (Xvm) which causes Xanthomonas wilt (XW) on banana (Musa accuminata x balbisiana) and enset (Ensete ventricosum), is closely related to the species Xanthomonas vasicola that contains the pathovars vasculorum (Xvv) and ...
Blondin, Laurence, Coutinho, Teresa A., Fuentes Rojas, Juan Luis, Mahuku, George, Nakato, Gloria Valentine, Vernière, Christian, Wicker, Emmanuel   +6 more
core   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Use of short tandem repeat sequences to study Mycobacterium leprae in leprosy patients in Malawi and India.

PLoS Neglected Tropical Diseases, 2008
BackgroundInadequate understanding of the transmission of Mycobacterium leprae makes it difficult to predict the impact of leprosy control interventions. Genotypic tests that allow tracking of individual bacterial strains would strengthen epidemiological
Saroj K Young, Jorg M Ponnighaus, Suman Jain, Sebastian Lucas, Sujai Suneetha, Diana N J Lockwood, Douglas B Young, Paul E M Fine   +7 more
doaj   +1 more source

Identifying Structural Variation in Haploid Microbial Genomes from Short-Read Resequencing Data Using Breseq [PDF]

, 2014
Mutations that alter chromosomal structure play critical roles in evolution and disease, including in the origin of new lifestyles and pathogenic traits in microbes.
Barrick, Jeffrey E., Borges, Jordan J., Colburn, Geoffrey, Deatherage, Daniel E., Knoester, David B., Meyer, Austin G., Reba, Aaron, Strand, Matthew D., Traverse, Charles C.   +8 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Indels, structural variation, and recombination drive genomic diversity inPlasmodium falciparum [PDF]

, 2016
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. Current understanding of parasite evolution is impeded by the fact that a large fraction of the genome is ...
Campino, Susana, Drury, Eleanor, Ferdig, Michael, Gould, Kelda, Hayton, Karen, Iqbal, Zamin, Kwiatkowski, Dominic, MacInnis, Bronwyn, McVean, Gil, Mead, Daniel, Miles, Alistair, Mwangi, Jonathan, O'Brien, John, Pearson, Richard, Ranford-Cartwright, Lisa, Rayner, Julian, Ruano Rubio, Valentin, Samarakoon, Upeka, Su, Xin-zhuan, Theron, Michel, Vauterin, Paul, Wellems, Thomas   +21 more
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tools for the identification of variable and potentially variable tandem repeats

BMC Genomics, 2006
Background Tandem repeat arrays showing variation between sequences within a population, between strains or across species may have functional effects. The increasing availability of genomic sequence data makes routine description of observed variation ...
Shields Denis C, O'Dushlaine Colm T
doaj   +1 more source