Results 61 to 70 of about 1,380,584 (288)
PLoS Neglected Tropical Diseases, 2008 BackgroundInadequate understanding of the transmission of Mycobacterium leprae makes it difficult to predict the impact of leprosy control interventions. Genotypic tests that allow tracking of individual bacterial strains would strengthen epidemiological
Saroj K Young +7 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Integrated multiple sequence alignment [PDF]
, 2005 Sammeth M. Integrated multiple sequence alignment. Bielefeld (Germany): Bielefeld University; 2005.The thesis presents enhancements for automated and manual multiple sequence alignment: existing alignment algorithms are made more easily accessible and ...
Sammeth, Michael
core
A fast and effective approach for the detection of units in tandem repeat proteins [PDF]
, 2022 openA fast and effective approach for the detection of units in tandem repeat proteinsA fast and effective approach for the detection of units in tandem repeat ...
COCCO, ALBERTO
core
Identification and characterisation of an extrachromosomal element from a multidrug-resistant isolate of Trypanosoma brucei brucei [PDF]
, 1995 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Drug resistance together with difficulties involved in the development of new trypanocides are a major problem in the present control of African ...
Jamnadass, Harmanjeet Ramni
core +7 more sources
Evolution and control of imprinted FWA genes in the genus Arabidopsis. [PDF]
PLoS Genetics, 2008 A central question in genomic imprinting is how a specific sequence is recognized as the target for epigenetic marking. In both mammals and plants, imprinted genes are often associated with tandem repeats and transposon-related sequences, but the role of
Ryo Fujimoto +9 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Tools for the identification of variable and potentially variable tandem repeats
BMC Genomics, 2006 Background Tandem repeat arrays showing variation between sequences within a population, between strains or across species may have functional effects. The increasing availability of genomic sequence data makes routine description of observed variation ...
Shields Denis C, O'Dushlaine Colm T
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Detecting Expansions of Tandem Repeats in Cohorts Sequenced with Short-Read Sequencing Data [PDF]
The American Journal of Human Genetics, 2018 Repeat expansions cause more than 30 inherited disorders, predominantly neurogenetic. These can present with overlapping clinical phenotypes, making molecular diagnosis challenging. Single-gene or small-panel PCR-based methods can help to identify the precise genetic cause, but they can be slow and costly and often yield no result.
Tankard, R.M. +5 more
openaire +2 more sources