Results 41 to 50 of about 90,014 (157)
Differentially Amplified Repetitive Sequences Among Aegilops tauschii Subspecies and Genotypes
Frontiers in Plant Science, 2021 Genomic repetitive sequences commonly show species-specific sequence type, abundance, and distribution patterns, however, their intraspecific characteristics have been poorly described.
Rahman Ebrahimzadegan +3 more
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Variable Tandem Repeats Accelerate Evolution of Coding and Regulatory Sequences
Annual Review of Genetics, 2010 Genotype-to-phenotype mapping commonly focuses on two major classes of mutations: single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we discuss an underestimated third class of genotypic variation: changes in microsatellite and minisatellite repeats.
Gemayel, Rita +3 more
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PLoS Neglected Tropical Diseases, 2008 BackgroundInadequate understanding of the transmission of Mycobacterium leprae makes it difficult to predict the impact of leprosy control interventions. Genotypic tests that allow tracking of individual bacterial strains would strengthen epidemiological
Saroj K Young +7 more
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Tools for the identification of variable and potentially variable tandem repeats
BMC Genomics, 2006 Background Tandem repeat arrays showing variation between sequences within a population, between strains or across species may have functional effects. The increasing availability of genomic sequence data makes routine description of observed variation ...
Shields Denis C, O'Dushlaine Colm T
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Evolution and control of imprinted FWA genes in the genus Arabidopsis. [PDF]
PLoS Genetics, 2008 A central question in genomic imprinting is how a specific sequence is recognized as the target for epigenetic marking. In both mammals and plants, imprinted genes are often associated with tandem repeats and transposon-related sequences, but the role of
Ryo Fujimoto +9 more
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Sequence Turnover and Tandem Repeats in cis-Regulatory Modules in Drosophila [PDF]
Molecular Biology and Evolution, 2005 The path by which regulatory sequence can change, yet preserve function, is an important open question for both evolution and bioinformatics. The recent sequencing of two additional species of Drosophila plus the wealth of data on gene regulation in the fruit fly provides new means for addressing this question.
Saurabh, Sinha, Eric D, Siggia
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Linked-read sequencing for detecting short tandem repeat expansions
Scientific Reports, 2022 AbstractDetection of short tandem repeat (STR) expansions with standard short-read sequencing is challenging due to the difficulty in mapping multicopy repeat sequences. In this study, we explored how the long-range sequence information of barcode linked-read sequencing (BLRS) can be leveraged to improve repeat-read detection.
Readman Chiu +3 more
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Sequencing technologies and tools for short tandem repeat variation detection [PDF]
Briefings in Bioinformatics, 2014 Short tandem repeats are highly polymorphic and associated with a wide range of phenotypic variation, some of which cause neurodegenerative disease in humans. With advances in high-throughput sequencing technologies, there are novel opportunities to study genetic variation.
Minh Duc Cao +2 more
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Detecting Expansions of Tandem Repeats in Cohorts Sequenced with Short-Read Sequencing Data [PDF]
The American Journal of Human Genetics, 2018 Repeat expansions cause more than 30 inherited disorders, predominantly neurogenetic. These can present with overlapping clinical phenotypes, making molecular diagnosis challenging. Single-gene or small-panel PCR-based methods can help to identify the precise genetic cause, but they can be slow and costly and often yield no result.
Tankard, R.M. +5 more
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Genomics, Proteomics & Bioinformatics, 2015 Massively parallel sequencing (MPS) technology is capable of determining the sizes of short tandem repeat (STR) alleles as well as their individual nucleotide sequences.
David H. Warshauer +4 more
doaj +1 more source