Results 51 to 60 of about 106,785 (200)

Repeat or not repeat?—Statistical validation of tandem repeat prediction in genomic sequences [PDF]

Nucleic Acids Research, 2012
Tandem repeats (TRs) represent one of the most prevalent features of genomic sequences. Due to their abundance and functional significance, a plethora of detection tools has been devised over the last two decades. Despite the longstanding interest, TR detection is still not resolved. Our large-scale tests reveal that current detectors produce different,
Schaper E., Kajava A.V., Hauser A., Anisimova M   +3 more
openaire   +6 more sources

Bovine proteins containing poly-glutamine repeats are often polymorphic and enriched for components of transcriptional regulatory complexes

, 2010
peer-reviewedBackground: About forty human diseases are caused by repeat instability mutations. A distinct subset of these diseases is the result of extreme expansions of polymorphic trinucleotide repeats; typically CAG repeats encoding poly-glutamine ...
Herman Raadsma, Raadsma Herman, Lynn David J, Hobbs, Matthew, Whan Vicki, McWilliam, Sean, Lynn, David J, Tellam, Ross L, Barendse William, Tellam Ross L, Ross L Tellam, Vicki Whan, McWilliam Sean, Khatkar Mehar, Lutzow Ylva, David J Lynn, William Barendse, Ylva Lutzow, Whan, Vicki, Khatkar, Mehar, Raadsma, Herman, Tellam, Ross L., Ylva Strandberg Lutzow, Barendse, William, Lutzow, Ylva Strandberg, Sean McWilliam, Lynn, David J., Lutzow, Ylva S, Matthew Hobbs, Hobbs Matthew, Mehar Khatkar   +30 more
core   +1 more source

Estimation of duplication history under a stochastic model for tandem repeats

BMC Bioinformatics, 2019
Background Tandem repeat sequences are common in the genomes of many organisms and are known to cause important phenomena such as gene silencing and rapid morphological changes. Due to the presence of multiple copies of the same pattern in tandem repeats
Farzad Farnoud, Moshe Schwartz, Jehoshua Bruck   +2 more
doaj   +1 more source

Multiple-locus variable-number tandem-repeat analysis of the swine dysentery pathogen, Brachyspira hyodysenteriae

, 2010
The spirochete Brachyspira hyodysenteriae is the causative agent of swine dysentery, a severe colonic infection of pigs that has a considerable economic impact in many swine-producing countries.
Rubio, P., Phillips, N.D., Ana Carvajal, Hidalgo, A., Germán Naharro, Tom La, Hampson, D.J., Álvaro Hidalgo, Pedro Rubio, Carvajal, A., La, T., David J. Hampson, Naharro, G., Nyree D. Phillips   +13 more
core   +1 more source

Short Tandem Repeats in Human Exons: A Target for Disease Mutations

BMC Genomics, 2008
Background In recent years it has been demonstrated that structural variations, such as indels (insertions and deletions), are common throughout the genome, but the implications of structural variations are still not clearly understood.
Villesen Palle, Madsen Bo, Wiuf Carsten
doaj   +1 more source

Efficient Synthesis of the Lewis A Tandem Repeat [PDF]

Molecules, 2016
The convergent synthesis of the Lewis A (Lea) tandem repeat is described. The Lea tandem repeat is a carbohydrate ligand for a mannose binding protein that shows potent inhibitory activity against carcinoma growth. The Lea unit, {β-d-Gal-(1→3)-[α-l-Fuc-(1→4)]-β-d-GlcNAc}, was synthesized by stereoselective nitrile-assisted β-galactosylation with the ...
Daisuke Kobayashi, Akiharu Ueki, Tomoya Yamaji, Kazuya Nagao, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Hideharu Ishida   +7 more
openaire   +3 more sources

Tandem repeats discovery service (TReaDS) applied to finding novel cis-acting factors in repeat expansion diseases

BMC Bioinformatics, 2012
Background Tandem repeats are multiple duplications of substrings in the DNA that occur contiguously, or at a short distance, and may involve some mutations (such as substitutions, insertions, and deletions).
Pellegrini Marco, Renda Maria Elena, Vecchio Alessio   +2 more
doaj   +1 more source

Functional and immunological relevance of Anaplasma marginale major surface protein 1a sequence and structural analysis.

PLoS ONE, 2013
Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A.
Alejandro Cabezas-Cruz, Lygia M F Passos, Katarzyna Lis, Rachel Kenneil, James J Valdés, Joana Ferrolho, Miray Tonk, Anna E Pohl, Libor Grubhoffer, Erich Zweygarth, Varda Shkap, Mucio F B Ribeiro, Agustín Estrada-Peña, Katherine M Kocan, José de la Fuente   +14 more
doaj   +1 more source

Tandem repeats features.

, 2015
*Presence of mismatches or indels or both in the repeated motifs1One mismatch2Four mismatches and one indel3One mismatch4One indelInv. repeats = Inverted repeatsTandem repeats features.
David C. Bloom (75605), Marco Tecilla (780088), Fabio Aloisio (780089), Patricia Otten (521848), Paola Pilo (383788), Ursula Sattler (780091), Paola Roccabianca (780092), Carlos H. Romero (780093), Francesco C. Origgi (287823), Lisandra Aguilar-Bultet (780090), Elliott R. Jacobson (495164)   +10 more
core   +1 more source

Identification of polymorphic tandem repeats by direct comparison of genome sequence from different bacterial strains : a web-based resource

BMC Bioinformatics, 2004
Background Polymorphic tandem repeat typing is a new generic technology which has been proved to be very efficient for bacterial pathogens such as B. anthracis, M. tuberculosis, P. aeruginosa, L. pneumophila, Y. pestis.
Vergnaud Gilles, Denœud France
doaj