Results 31 to 40 of about 6,075,366 (305)
Regulation of Dpp target genes by Mad/Medea and Brinker [PDF]
, 2009 The TGF-β family member Decapentaplegic (Dpp) is a key regulator of patterning and growth in development of Drosophila. Binding of Dpp to its receptors triggers the activation of the intracellular Smad pathway.
Weiss, Alexander
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Targeting Sh2 Domains in Breast Cancer [PDF]
Future Medicinal Chemistry, 2014 Breast cancer is among the most commonly diagnosed cancer types in women worldwide and is the second leading cause of cancer-related disease in the USA. SH2 domains recruit signaling proteins to phosphotyrosine residues on aberrantly activated growth factor and cytokine receptors and contribute to cancer cell cycling, metastasis, angiogenesis and so on.
Pietro, Morlacchi +3 more
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Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach [PDF]
, 2011 Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...
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Lipid droplet targeting domains of adipophilin [PDF]
Journal of Lipid Research, 2003 Adipophilin (ADPH), a prominent protein component of lipid storage droplets (LSDs), is postulated to be necessary for the formation and cellular function of these structures. The presence of significant sequence similarities within an approximately 100 amino acid region of the N-terminal portions of ADPH and related LSD binding proteins, perilipin and ...
James L. McManaman +3 more
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Multi-Domain Targeted Sentiment Analysis
Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, 2022 Accepted to NAACL 2022 (long paper)
Orith Toledo-Ronen +3 more
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Metaphorization origins: Key points. Translation and comments by L.V. Kalashnikova [PDF]
Актуальные проблемы филологии и педагогической лингвистикиThe essence of metaphor’s reliance on two domains, a source and a target, is argued as stemming from a fundamental characteristic of higher cognition—that of conceptualizing more than one cognitive/embodied domain at the same time. This cognitive duality
Herbert L. Colston
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Domain-Invariant Feature Learning for Domain Adaptation
, 2023 Unsupervised domain adaptation (UDA) explores mainly how to learn domain-invariant features from the source domain when the target domain label is unknown.
Ching-Ting Tu; Hsiau-Wen Lin; Hwei Jen Lin; Yoshimasa Tokuyama; Chia-Hung Chu
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METAPHORISATION OF BREXIT IN MODERN POLITICAL DISCOURSE
Novìtnâ Osvìta, 2018 The article deals with an interdisciplinary perspective to a political discourse presenting conceptual metaphors as a powerful and effective means for conceptualising life experience of modern society. The focus of the study is on the analysis of topics
Olha Bilyk, Nataliia Pyliachyk
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Regularised transfer learning for hyperspectral image classification
IET Computer Vision, 2019 This study presents a transfer learning method for addressing the insufficient sample problem in hyperspectral image classification. In order to find common feature representation for both the source domain and target domain, we introduce a ...
Qian Shi +3 more
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Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure [PDF]
, 2010 The mineralocorticoid receptor (MR) binds the steroid hormones aldosterone and cortisol and has an important physiological role in the control of salt homeostasis.
Fischer, Katharina +14 more
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