Lipid droplet targeting domains of adipophilin [PDF]
Adipophilin (ADPH), a prominent protein component of lipid storage droplets (LSDs), is postulated to be necessary for the formation and cellular function of these structures. The presence of significant sequence similarities within an approximately 100 amino acid region of the N-terminal portions of ADPH and related LSD binding proteins, perilipin and ...
James L. McManaman +3 more
openaire +3 more sources
CATHEDRAL: A fast and effective algorithm to predict folds and domain boundaries from multidomain protein structures [PDF]
We present CATHEDRAL, an iterative protocol for determining the location of previously observed protein folds in novel multidomain protein structures. CATHEDRAL builds on the features of a fast secondary-structure-based method ( using graph theory) to ...
Oliver C Redfern +22 more
core +1 more source
p160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain [PDF]
Transcriptional activation involves the ordered recruitment of coactivators via direct interactions between distinct binding domains and recognition motifs.
Coudevylle, N. +12 more
core +1 more source
FES-TSA target domain logits [PDF]
Cached target domain logits for ConFES and ...
Anonymous, Anonymous
core +1 more source
Regulation of Dpp target genes by Mad/Medea and Brinker [PDF]
The TGF-β family member Decapentaplegic (Dpp) is a key regulator of patterning and growth in development of Drosophila. Binding of Dpp to its receptors triggers the activation of the intracellular Smad pathway.
Weiss, Alexander
core +1 more source
Domain is a moving target for relational learning [PDF]
The domain for relational learning was manipulated by varying the training set size for pigeons that had learned the same/different (S/D) concept. Six pigeons that had learned a S/D task with pairs of pictures with a set size of 1024 picture items had their training set size reduced to 8 items.
Katz, Jeffrey S. +2 more
openaire +3 more sources
Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach [PDF]
Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...
core +2 more sources
Generalizability of Deep Domain Adaptation in case of Sample Selection Bias [PDF]
Domain adaptation allows machine learning models to perform well in a domain that is different from the available train data. This non-trivial task is approached in many ways and often relies on assumptions about the source (train) and target (test ...
Witting, Emiel (author)
core
Metaphorization origins: Key points. Translation and comments by L.V. Kalashnikova [PDF]
The essence of metaphor’s reliance on two domains, a source and a target, is argued as stemming from a fundamental characteristic of higher cognition—that of conceptualizing more than one cognitive/embodied domain at the same time. This cognitive duality
Herbert L. Colston
doaj +1 more source
Unsupervised Heterogeneous Domain Adaptation with Fuzzy Rule Learning [PDF]
Heterogeneous domain adaptation is a technique that uses the knowledge of source domain to model the target domain. The source domain and the target domain are semantically related, but their feature spaces are different.
SUN Wu, DENG Zhaohong, LOU Qiongdan, GU Xin, WANG Shitong
doaj +1 more source

