Results 91 to 100 of about 4,789,466 (273)

In Situ Interfacial Assembly of Dynamic Semi‐Interpenetrating Biopolymer Networks for Robust and Mechanically Adaptive Droplet Interfaces

Advanced Functional Materials, EarlyView.
A dynamic interfacial semi‐interpenetrating polymer network is constructed by sequential assembly of β‐sheet‐rich SF and CS‐RL. The SF framework provides mechanical strength, while dynamically associated CS‐RL enables local rearrangement, allowing droplets to rapidly reconfigure without loss of interfacial integrity.
Yaping Zhang, Yujie Liu, Yikai Xu, Xunda Feng, Ling Zhang, Hongbo Zeng, Hao Liu, Xiaohui Mao   +7 more
wiley   +1 more source

CHoledocholithiasis - Observation vs. Intervention in the Elderly (CHOIcE): A target trial emulation

There is currently clinical uncertainty as to which approach is better in elderly patients with asymptomatic choledocholithiasis: up-front ERCP or observation.
Zachary Smith
core   +1 more source

Metronomic paclitaxel and cisplatin chemotherapy for metastatic breast cancer: insights from a target trial emulation

The Lancet Regional Health. Western Pacific
Background: The management of metastatic breast cancer (MBC) poses a significant clinical challenge due to its high incidence of drug resistance and the limited efficacy of conventional therapies.
Yaorong Li, Liang Zhu, Wenjin Yin, Yaohui Wang, Jingsong Lu   +4 more
doaj   +1 more source

Time Partitioning in Target Trial Emulation

In target trial emulation, time partitioning enables researchers to handle time-varying confounders and immortal time bias with appropriate methods. Based on two clinical scenarios, this study aimed to explore issues related to time partitioning and to provide guidance for trial emulation. After formalizing the research question within the framework of
Zoumenou, Harold Tankpinou, Ferreira, Simon, Assaad, Charles, Lapidus, Nathanael, Bystrova, Daria, Glemain, Benjamin   +5 more
openaire   +2 more sources

Target Trial Emulation to Assess Oral Drug Safety

Journal of Dental Research
Trials that use a randomization process are preferred for evaluating causal effect. However, these interventional studies are not always feasible due to ethical, time, and cost constraints. Additionally, they are often criticized for not accurately representing patients seen in clinical practice. Observational studies can help bridge this gap, but they
I. Leiva-Escobar, A. Puzhakkara Chennas, S.L. Reckelkamm, L. Gelberg, S.-E. Baumeister, M. Nolde   +5 more
openaire   +2 more sources

Material Coupling in Hybrid Neuromorphic Devices: From Fundamentals to System‐Level Applications

Advanced Functional Materials, EarlyView.
Hybrid neuromorphic devices utilize heterointerfaces between emerging semiconductors, where charge transfer and trapping, ion or defect modulation, and photogating are translated into synaptic functions. This paper discusses coupling strategies that tailor interfacial electronic and ionic properties in organic semiconductors, metal oxides, two ...
Minsu So, Sunwoo Jeong, Youngmin Han, Fabrizio Torricelli, Hocheon Yoo, Junhwan Choi   +5 more
wiley   +1 more source

Association of antibiotic type and timing with sepsis mortality using target trial emulation

Scientific Reports
Antibiotic therapy is essential for sepsis management, but the optimal empirical strategy remains uncertain. This study evaluated the effects of first-line antibiotic preference and initiation timing on in-hospital mortality among intensive care units ...
Jiayang Li, Mingyi Zhao, Qingnan He
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform

Advanced Healthcare Materials, EarlyView.
A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu, Xinggui Tian, Anne Bernhardt, Anja Lode, Max von Witzleben, Ege Kirbas, Stefan Zwingenberger, Michael Gelinsky   +7 more
wiley   +1 more source

Target trial emulation: bridging observational studies and randomized trials for health decision-making

Journal of Comparative Effectiveness Research
Randomized controlled trials (RCTs) are the gold standard generating evidence owing to their rigorous methodology. However, their logistical, financial and ethical limitations highlight the need for alternative approaches using real-world data.
Emilia Riggi, Eva Segelov, Gian Luca Di Tanna   +2 more
doaj   +1 more source